Int. J. Mol. Sci. 2012, 13(11), 15042-15053; doi:10.3390/ijms131115042
Article

Antifungal Activity of (KW)n or (RW)n Peptide against Fusarium solani and Fusarium oxysporum

1email, 2email, 3email and 1,2,* email
Received: 16 July 2012; in revised form: 14 August 2012 / Accepted: 17 October 2012 / Published: 15 November 2012
(This article belongs to the Special Issue Green Biocides)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The presence of lysine (Lys) or arginine (Arg) and tryptophan (Trp) are important for the antimicrobial effects of cationic peptides. Therefore, we designed and synthesized a series of antimicrobial peptides with various numbers of Lys (or Arg) and Trp repeats [(KW and RW)n-NH2, where n equals 2, 3, 4, or 5]. Antifungal activities of these peptides increased with chain length. Light microscopy demonstrated that longer peptides (n = 4, 5) strongly inhibited in vitro growth of Fusarium solani, and Fusarium oxysporum, at 4–32 μM. Furthermore, longer peptides displayed potent fungicidal activities against a variety of agronomical important filamentous fungi, including F. solani and F. oxysporum, at their minimal inhibitory concentrations (MICs). However, RW series peptides showed slightly higher fungicidal activities than KW peptides against the two strains. Taken together, the results of this study indicate that these short peptides would be good candidates for use as synthetic or transgenic antifungal agents.
Keywords: lysine; arginine; tryptophan; antifungal peptides; fungicidal
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MDPI and ACS Style

Gopal, R.; Na, H.; Seo, C.H.; Park, Y. Antifungal Activity of (KW)n or (RW)n Peptide against Fusarium solani and Fusarium oxysporum. Int. J. Mol. Sci. 2012, 13, 15042-15053.

AMA Style

Gopal R, Na H, Seo CH, Park Y. Antifungal Activity of (KW)n or (RW)n Peptide against Fusarium solani and Fusarium oxysporum. International Journal of Molecular Sciences. 2012; 13(11):15042-15053.

Chicago/Turabian Style

Gopal, Ramamourthy; Na, Hyungjong; Seo, Chang H.; Park, Yoonkyung. 2012. "Antifungal Activity of (KW)n or (RW)n Peptide against Fusarium solani and Fusarium oxysporum." Int. J. Mol. Sci. 13, no. 11: 15042-15053.

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