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The Role of Antimicrobial Peptides in Preventing Multidrug-Resistant Bacterial Infections and Biofilm Formation
Research Center for Proteineous Materials, Chosun University, Gwangju 501-759, Korea
Department of Biotechnology, Chosun University, Gwangju 501-759, Korea
Bioleaders Corporation, 559 Yongsan-Dong, Yusong-Ku, Daejeon 305-500, Korea
* Authors to whom correspondence should be addressed.
Received: 21 July 2011; in revised form: 5 September 2011 / Accepted: 6 September 2011 / Published: 16 September 2011
(This article belongs to the Special Issue Biocides
Abstract: Over the last decade, decreasing effectiveness of conventional antimicrobial-drugs has caused serious problems due to the rapid emergence of multidrug-resistant pathogens. Furthermore, biofilms, which are microbial communities that cause serious chronic infections and dental plaque, form environments that enhance antimicrobial resistance. As a result, there is a continuous search to overcome or control such problems, which has resulted in antimicrobial peptides being considered as an alternative to conventional drugs. Antimicrobial peptides are ancient host defense effector molecules in living organisms. These peptides have been identified in diverse organisms and synthetically developed by using peptidomimic techniques. This review was conducted to demonstrate the mode of action by which antimicrobial peptides combat multidrug-resistant bacteria and prevent biofilm formation and to introduce clinical uses of these compounds for chronic disease, medical devices, and oral health. In addition, combinations of antimicrobial peptides and conventional drugs were considered due to their synergetic effects and low cost for therapeutic treatment.
Keywords: mode of action; lipopolysaccharide; quorum sensing; dental plaque; synergetic effect
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MDPI and ACS Style
Park, S.-C.; Park, Y.; Hahm, K.-S. The Role of Antimicrobial Peptides in Preventing Multidrug-Resistant Bacterial Infections and Biofilm Formation. Int. J. Mol. Sci. 2011, 12, 5971-5992.
Park S-C, Park Y, Hahm K-S. The Role of Antimicrobial Peptides in Preventing Multidrug-Resistant Bacterial Infections and Biofilm Formation. International Journal of Molecular Sciences. 2011; 12(9):5971-5992.
Park, Seong-Cheol; Park, Yoonkyung; Hahm, Kyung-Soo. 2011. "The Role of Antimicrobial Peptides in Preventing Multidrug-Resistant Bacterial Infections and Biofilm Formation." Int. J. Mol. Sci. 12, no. 9: 5971-5992.