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Int. J. Mol. Sci. 2011, 12(1), 668-681; doi:10.3390/ijms12010668
Article

Combined Effects of Cyclooxygenase-1 and Cyclooxygenase-2 Selective Inhibitors on Ovarian Carcinoma in Vivo

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Received: 30 November 2010 / Revised: 28 December 2010 / Accepted: 10 January 2011 / Published: 18 January 2011
(This article belongs to the Special Issue Cancer Molecules in Ovarian Cancer)
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Abstract

The present study was designed to investigate the combined effects of cyclooxygenase (COX)-1 and COX-2 selective inhibitors on human ovarian SKOV-3 carcinoma cells xenograft-bearing mice. The animals were treated with 3 mg/kg SC-560 (a COX-1 selective inhibitor) alone, 25 mg/kg celecoxib (a COX-2 selective inhibitor) alone, or SC-560/celecoxib by gavage, twice a day for three weeks. To test the mechanism of inhibition of tumor growth by COX selective inhibitors, the index of proliferating cells in tumor tissues was determined by immunostaining and the index of apoptotic cells by the terminal-deoxynucleotidyl-transferase-mediated deoxyuridine triphosphate nick end labeling (TUNEL) method. The inhibitory rate on tumor growth in the combination group was 35.54% which is significant statistically compared with that of the control group (P < 0.05). In the combination group, the index of cell proliferation and apoptosis were 12.40% and 51.03% respectively, which are significant statistically compared with those of the control group (22.56%, 19.07%, all P < 0.05). These studies indicate that synergism between two COX inhibitors and inhibitor combination treatment has particular potential for chemoprevention of ovarian cancer growth.
Keywords: ovarian carcinoma; mice; cyclooxygenase selective inhibitor; cell proliferation; apoptosis ovarian carcinoma; mice; cyclooxygenase selective inhibitor; cell proliferation; apoptosis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Li, W.; Wang, J.; Jiang, H.-R.; Xu, X.-L.; Zhang, J.; Liu, M.-L.; Zhai, L.-Y. Combined Effects of Cyclooxygenase-1 and Cyclooxygenase-2 Selective Inhibitors on Ovarian Carcinoma in Vivo. Int. J. Mol. Sci. 2011, 12, 668-681.

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