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Int. J. Mol. Sci. 2011, 12(1), 410-428; doi:10.3390/ijms12010410

Exploring the Immunoproteome for Ovarian Cancer Biomarker Discovery

1 Adelaide Proteomics Centre, School of Molecular and Biomedical Science, University of Adelaide, Adelaide, Australia 2 Research Centre for Reproductive Health, School of Paediatrics and Reproductive Health, Robinson Institute, University of Adelaide, Adelaide, Australia 3 Department of Gynaecological Oncology, Royal Adelaide Hospital, Adelaide, Australia
* Author to whom correspondence should be addressed.
Received: 30 November 2010 / Accepted: 12 January 2011 / Published: 14 January 2011
(This article belongs to the Special Issue Cancer Molecules in Ovarian Cancer)
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Most scientific efforts towards early detection of ovarian cancer are commonly focused on the discovery of tumour-associated antigens (TAA). Autologous antibodies against TAA, however, may serve as more sensitive diagnostic markers. They circulate in the blood before TAA and are usually more abundant than the TAAs themselves as a result of amplification through the humoral immune response. Accumulating evidence also suggests that a humoral response already exists during malignant transformation when aberrant gene expression is translated into premalignant cellular changes. This article reviews the current knowledge about autoantibodies against TAA in ovarian cancer and presents current immunoproteomic approaches for their detection.
Keywords: ovarian cancer; autoantibodies; immunoproteomics ovarian cancer; autoantibodies; immunoproteomics
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Martin, K.; Ricciardelli, C.; Hoffmann, P.; Oehler, M.K. Exploring the Immunoproteome for Ovarian Cancer Biomarker Discovery. Int. J. Mol. Sci. 2011, 12, 410-428.

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