Int. J. Mol. Sci. 2009, 10(2), 407-440; doi:10.3390/ijms10020407
Review

Drosophila melanogaster as a Model Organism of Brain Diseases

Received: 30 December 2008; in revised form: 16 January 2009 / Accepted: 20 January 2009 / Published: 2 February 2009
(This article belongs to the Special Issue Advances in Molecular Neuropathology)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Drosophila melanogaster has been utilized to model human brain diseases. In most of these invertebrate transgenic models, some aspects of human disease are reproduced. Although investigation of rodent models has been of significant impact, invertebrate models offer a wide variety of experimental tools that can potentially address some of the outstanding questions underlying neurological disease. This review considers what has been gleaned from invertebrate models of neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, metabolic diseases such as Leigh disease, Niemann-Pick disease and ceroid lipofuscinoses, tumor syndromes such as neurofibromatosis and tuberous sclerosis, epilepsy as well as CNS injury. It is to be expected that genetic tools in Drosophila will reveal new pathways and interactions, which hopefully will result in molecular based therapy approaches.
Keywords: Fly; drosophila; brain disease
PDF Full-text Download PDF Full-Text [852 KB, uploaded 19 June 2014 01:40 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Jeibmann, A.; Paulus, W. Drosophila melanogaster as a Model Organism of Brain Diseases. Int. J. Mol. Sci. 2009, 10, 407-440.

AMA Style

Jeibmann A, Paulus W. Drosophila melanogaster as a Model Organism of Brain Diseases. International Journal of Molecular Sciences. 2009; 10(2):407-440.

Chicago/Turabian Style

Jeibmann, Astrid; Paulus, Werner. 2009. "Drosophila melanogaster as a Model Organism of Brain Diseases." Int. J. Mol. Sci. 10, no. 2: 407-440.

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert