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Int. J. Mol. Sci. 2009, 10(1), 366-384; doi:10.3390/ijms10010366
Review

The Importance of Brain Banks for Molecular Neuropathological Research: The New South Wales Tissue Resource Centre Experience

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Received: 19 December 2008 / Revised: 14 January 2009 / Accepted: 22 January 2009 / Published: 23 January 2009
(This article belongs to the Special Issue Advances in Molecular Neuropathology)
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Abstract

New developments in molecular neuropathology have evoked increased demands for postmortem human brain tissue. The New South Wales Tissue Resource Centre (TRC) at The University of Sydney has grown from a small tissue collection into one of the leading international brain banking facilities, which operates with best practice and quality control protocols. The focus of this tissue collection is on schizophrenia and allied disorders, alcohol use disorders and controls. This review highlights changes in TRC operational procedures dictated by modern neuroscience, and provides examples of applications of modern molecular techniques to study the neuropathogenesis of many different brain disorders.
Keywords: Human; brain bank; schizophrenia; alcohol; postmortem; molecular neuropathology; genome; proteome; receptor binding; clinical characterization Human; brain bank; schizophrenia; alcohol; postmortem; molecular neuropathology; genome; proteome; receptor binding; clinical characterization
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Dedova, I.; Harding, A.; Sheedy, D.; Garrick, T.; Sundqvist, N.; Hunt, C.; Gillies, J.; Harper, C.G. The Importance of Brain Banks for Molecular Neuropathological Research: The New South Wales Tissue Resource Centre Experience. Int. J. Mol. Sci. 2009, 10, 366-384.

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