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Recent Advances in Synthetic Bioelastomers
Laboratory of Bone Tissue Engineering of Beijing Research Institute of Traumatology and Orthopaedics, Beijing 100035, China
Beijing Key Laboratory on Preparation and Processing of Novel Polymer Materials at Beijing University of Chemical Technology, 100029, China
Department of Spine Surgery of Beijing JiShuiTan Hospital, the Fourth Clinical Medical College of Peking University, Beijing 100035, China
* Authors to whom correspondence should be addressed.
Received: 4 August 2009; in revised form: 30 August 2009 / Accepted: 8 September 2009 / Published: 29 September 2009
Abstract: This article reviews the degradability of chemically synthesized bioelastomers, mainly designed for soft tissue repair. These bioelastomers involve biodegradable polyurethanes, polyphosphazenes, linear and crosslinked poly(ether/ester)s, poly(ε-caprolactone) copolymers, poly(1,3-trimethylene carbonate) and their copolymers, poly(polyol sebacate)s, poly(diol-citrates) and poly(ester amide)s. The in vitro and in vivo degradation mechanisms and impact factors influencing degradation behaviors are discussed. In addition, the molecular designs, synthesis methods, structure properties, mechanical properties, biocompatibility and potential applications of these bioelastomers were also presented.
Keywords: bioelastomer; biodegradable; biocompatible; polyurethanes; polyphosphazenes; poly(ether ester); poly(ε-caprolactone); poly(1,3-trimethylene carbonate); poly(polyol sebacate)s; poly(diol-citrates); poly(ester amide)s
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Shi, R.; Chen, D.; Liu, Q.; Wu, Y.; Xu, X.; Zhang, L.; Tian, W. Recent Advances in Synthetic Bioelastomers. Int. J. Mol. Sci. 2009, 10, 4223-4256.
Shi R, Chen D, Liu Q, Wu Y, Xu X, Zhang L, Tian W. Recent Advances in Synthetic Bioelastomers. International Journal of Molecular Sciences. 2009; 10(10):4223-4256.
Shi, Rui; Chen, Dafu; Liu, Quanyong; Wu, Yan; Xu, Xiaochuan; Zhang, Liqun; Tian, Wei. 2009. "Recent Advances in Synthetic Bioelastomers." Int. J. Mol. Sci. 10, no. 10: 4223-4256.