Int. J. Mol. Sci. 2009, 10(1), 1-17; doi:10.3390/ijms10010001
Article

Impact of Deoxynivalenol on the Intestinal Microflora of Pigs

Yann J. Waché 1,2 email, Charlotte Valat 1,* email, Gilbert Postollec 1 email, Stephanie Bougeard 1 email, Christine Burel 1 email, Isabelle P. Oswald 2 email and Philippe Fravalo 1 email
1 French Agency for Food Safety (AFSSA) – Zoopôle des côtes d’Armor, BP53, 22440 Ploufragan – France 2 French Institute of Agricultural Research (INRA) – UR 66- Unité de Pharmacologie-Toxicologie, 180 chemin de Tournefeuille, 31027 Toulouse cedex 3 – France
* Author to whom correspondence should be addressed.
Received: 6 November 2008; in revised form: 22 December 2008 / Accepted: 24 December 2008 / Published: 27 December 2008
(This article belongs to the Special Issue Mycotoxins: Mechanisms of Toxicological Activity - Treatment and Prevention)
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Abstract: Deoxynivalenol (DON), a mycotoxin produced by some Fusarium species, is a frequent contaminant of cereal. In the present study, 24 weanling piglets received either control feed or feed naturally contaminated with DON (2.8 mg/kg) for four weeks. Consumption of contaminated feed significantly reduced the animal weight gain during the first week of the experiment, but had a moderate effect on cultivable bacteria in the pig intestine. By contrast, changes in the intestinal microflora were observed by Capillary Electrophoresis Single-Stranded Conformation Polymorphism (CE-SSCP) in DON-exposed animals, suggesting an impact of this toxin on the dynamics of intestinal bacteria communities.
Keywords: Mycotoxin; Deoxynivalenol; pigs; intestinal microflora; growth performance; faeces; anaerobic sulfite-reducing bacteria; CE-SSCP

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Cite This Article

MDPI and ACS Style

Waché, Y.J.; Valat, C.; Postollec, G.; Bougeard, S.; Burel, C.; Oswald, I.P.; Fravalo, P. Impact of Deoxynivalenol on the Intestinal Microflora of Pigs. Int. J. Mol. Sci. 2009, 10, 1-17.

AMA Style

Waché YJ, Valat C, Postollec G, Bougeard S, Burel C, Oswald IP, Fravalo P. Impact of Deoxynivalenol on the Intestinal Microflora of Pigs. International Journal of Molecular Sciences. 2009; 10(1):1-17.

Chicago/Turabian Style

Waché, Yann J.; Valat, Charlotte; Postollec, Gilbert; Bougeard, Stephanie; Burel, Christine; Oswald, Isabelle P.; Fravalo, Philippe. 2009. "Impact of Deoxynivalenol on the Intestinal Microflora of Pigs." Int. J. Mol. Sci. 10, no. 1: 1-17.

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