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Molecules 2004, 9(8), 650-657; doi:10.3390/90800650
Article

Isolation and X-ray Crystal Structure of Tetrahydroisoquinoline Alkaloids from Calycotome Villosa Subsp. intermedias

1, 1, 1, 2, 3, 1 and 1,*
1 Laboratoire d´Analyses, d’Essais et d’Environnement (L.A.E.E.), Département de Chimie, Faculté des Sciences “Dhar Mehraz”, Université Sidi Mohamed Ben Abdellah, 30000 Fès, Morocco 2 Département de Biologie, Faculté des Sciences “Dhar Mehraz”, Université Sidi Mohamed Ben Abdellah, 30000 Fès, Morocco 3 Institut für Organische Chemie, J. W. Goethe-Universität Frankfurt, Marie-Curie-Straße 11, 60439, Frankfurt/Main, Germany
* Author to whom correspondence should be addressed.
Received: 18 December 2003 / Revised: 6 July 2004 / Accepted: 11 July 2004 / Published: 31 July 2004
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Abstract

Two tetrahydroisoquinoline alkaloids were extracted from the alkaloid fraction of a methanol extract of the seeds of Calycotome Villosa Subsp. intermedia. Their structures were established as (R)-1-hydroxymethyl-7-8-dimethoxy-1,2,3,4-tetrahydro- isoquinoline (1) and (S)-7-hydroxymethyl-2-3-dimethoxy-7,8,9,10-tetrahydroisoquinoline chloride (2) by spectroscopic techniques and X-ray diffraction analysis.
Keywords: Calycotome villosa (Poiret) Link Subsp. Intermedia; alkaloids; tetrahydroisoquinoline; spectroscopy; X-ray crystal structure determination. Calycotome villosa (Poiret) Link Subsp. Intermedia; alkaloids; tetrahydroisoquinoline; spectroscopy; X-ray crystal structure determination.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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El Antri, A.; Messouri, I.; Bouktaib, M.; El Alami, R.; Bolte, M.; El Bali, B.; Lachkar, M. Isolation and X-ray Crystal Structure of Tetrahydroisoquinoline Alkaloids from Calycotome Villosa Subsp. intermedias. Molecules 2004, 9, 650-657.

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