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Molecules 2004, 9(8), 650-657; doi:10.3390/90800650
Article

Isolation and X-ray Crystal Structure of Tetrahydroisoquinoline Alkaloids from Calycotome Villosa Subsp. intermedias

1, 1, 1, 2, 3, 1 and 1,*
1 Laboratoire d´Analyses, d’Essais et d’Environnement (L.A.E.E.), Département de Chimie, Faculté des Sciences “Dhar Mehraz”, Université Sidi Mohamed Ben Abdellah, 30000 Fès, Morocco 2 Département de Biologie, Faculté des Sciences “Dhar Mehraz”, Université Sidi Mohamed Ben Abdellah, 30000 Fès, Morocco 3 Institut für Organische Chemie, J. W. Goethe-Universität Frankfurt, Marie-Curie-Straße 11, 60439, Frankfurt/Main, Germany
* Author to whom correspondence should be addressed.
Received: 18 December 2003 / Revised: 6 July 2004 / Accepted: 11 July 2004 / Published: 31 July 2004
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Abstract

Two tetrahydroisoquinoline alkaloids were extracted from the alkaloid fraction of a methanol extract of the seeds of Calycotome Villosa Subsp. intermedia. Their structures were established as (R)-1-hydroxymethyl-7-8-dimethoxy-1,2,3,4-tetrahydro- isoquinoline (1) and (S)-7-hydroxymethyl-2-3-dimethoxy-7,8,9,10-tetrahydroisoquinoline chloride (2) by spectroscopic techniques and X-ray diffraction analysis.
Keywords: Calycotome villosa (Poiret) Link Subsp. Intermedia; alkaloids; tetrahydroisoquinoline; spectroscopy; X-ray crystal structure determination. Calycotome villosa (Poiret) Link Subsp. Intermedia; alkaloids; tetrahydroisoquinoline; spectroscopy; X-ray crystal structure determination.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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El Antri, A.; Messouri, I.; Bouktaib, M.; El Alami, R.; Bolte, M.; El Bali, B.; Lachkar, M. Isolation and X-ray Crystal Structure of Tetrahydroisoquinoline Alkaloids from Calycotome Villosa Subsp. intermedias. Molecules 2004, 9, 650-657.

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