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Molecules 2004, 9(8), 658-665; doi:10.3390/90800658
Article

Synthesis of Substituted Stilbenes via the Knoevenagel Condensation

Received: 15 January 2004; in revised form: 4 July 2004 / Accepted: 8 July 2004 / Published: 31 July 2004
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Abstract: Knoevenagel condensations between aldehydes and substrates containing active methylene groups were carried out in ethanol at room temperature, in the presence of potassium phosphate, to afford unsymmetrical olefins. These condensations have been shown to afford only the E-isomers in greater than 80% yields. Salicylaldehyde first produces the Knoevenagel condensation products, which undergo a subsequent heterocyclization to give coumarin derivatives. The structures of the synthesized compounds were established on the basis of UV, IR, MS and NMR spectroscopy.
Keywords: Knoevenagel condensation; E-stilbenes; coumarins; potassium phosphate. Knoevenagel condensation; E-stilbenes; coumarins; potassium phosphate.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Al-Shihry, S.S. Synthesis of Substituted Stilbenes via the Knoevenagel Condensation. Molecules 2004, 9, 658-665.

AMA Style

Al-Shihry SS. Synthesis of Substituted Stilbenes via the Knoevenagel Condensation. Molecules. 2004; 9(8):658-665.

Chicago/Turabian Style

Al-Shihry, Shar S. 2004. "Synthesis of Substituted Stilbenes via the Knoevenagel Condensation." Molecules 9, no. 8: 658-665.


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