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Molecules 2004, 9(8), 658-665; doi:10.3390/90800658

Synthesis of Substituted Stilbenes via the Knoevenagel Condensation

Department of Chemistry, College of Science, King Faisal University, P.O. Box 1759, Hofuf 31982, Saudi Arabia
Received: 15 January 2004 / Revised: 4 July 2004 / Accepted: 8 July 2004 / Published: 31 July 2004
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Knoevenagel condensations between aldehydes and substrates containing active methylene groups were carried out in ethanol at room temperature, in the presence of potassium phosphate, to afford unsymmetrical olefins. These condensations have been shown to afford only the E-isomers in greater than 80% yields. Salicylaldehyde first produces the Knoevenagel condensation products, which undergo a subsequent heterocyclization to give coumarin derivatives. The structures of the synthesized compounds were established on the basis of UV, IR, MS and NMR spectroscopy.
Keywords: Knoevenagel condensation; E-stilbenes; coumarins; potassium phosphate. Knoevenagel condensation; E-stilbenes; coumarins; potassium phosphate.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Al-Shihry, S.S. Synthesis of Substituted Stilbenes via the Knoevenagel Condensation. Molecules 2004, 9, 658-665.

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