Molecules 2004, 9(1), 11-21; doi:10.3390/90100011
Article

Reaction of Substituted Furan-2-carboxaldehydes and Furo[b]pyrrole Type Aldehydes with Hippuric Acid

1, 2 and 1,* email
Received: 20 October 2003; in revised form: 14 January 2004 / Accepted: 15 January 2004 / Published: 31 January 2004
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: 4-Heteroarylidene-2-phenyl-1,3-oxazol-5(4H)-ones were prepared by reactions of hippuric acid with substituted furan-2-carboxaldehydes or furo[b]pyrrole type aldehydes. The reactivity of various furan-2-carboxaldehyde derivatives in this reaction is discussed. The effect of microwave irradiation on some condensation reactions was compared with “classical” conditions. The results show that microwave irradiation shortens the reaction times while affording comparable yields. Elementary analysis, UV, IR and 1D NMR proved the structure of new synthesised compounds. 2D NMR spectroscopic measurements confirmed that the configuration at the carbon-carbon double bond corresponds to the pure E isomers of the products.
Keywords: 5-Arylfuran-2-carboxaldehydes; furo[3; 2-b]pyrrole-2-carboxaldehydes; furo- [2; 3-b]pyrrole-2-carboxaldehydes; hippuric acid; microwave irradiation; 1; 3-oxazol- 5(4H)-ones; furo[3; 2-b]pyrrole-5-carboxylates; furo[2; 3-b]pyrrole-5-carboxylates; 1H- and 13 C-NMR; COSY; NOESY; HSQC; HMBC.
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MDPI and ACS Style

Puterová, Z.; Sterk, H.; Krutošíková, A. Reaction of Substituted Furan-2-carboxaldehydes and Furo[b]pyrrole Type Aldehydes with Hippuric Acid. Molecules 2004, 9, 11-21.

AMA Style

Puterová Z, Sterk H, Krutošíková A. Reaction of Substituted Furan-2-carboxaldehydes and Furo[b]pyrrole Type Aldehydes with Hippuric Acid. Molecules. 2004; 9(1):11-21.

Chicago/Turabian Style

Puterová, Zita; Sterk, Heinz; Krutošíková, Alžbeta. 2004. "Reaction of Substituted Furan-2-carboxaldehydes and Furo[b]pyrrole Type Aldehydes with Hippuric Acid." Molecules 9, no. 1: 11-21.

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