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Molecules 2003, 8(6), 472-479; doi:10.3390/80600472

Synthesis and Biological Evaluation of New 4,5-Disubstituted-Thiazolyl Amides, Derivatives of 4-Hydroxy-Piperidine or of 4-N-Methyl Piperazine

Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotelian University of Thessaloniki, Thessaloniki 54124, Greece
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Received: 13 May 2003 / Revised: 15 May 2003 / Accepted: 16 May 2003 / Published: 30 June 2003
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Abstract

4,5-disubstituted-thizolyl amides, derivatives of 4-hydroxy-piperidine and of 4-N-methyl piperazine, were synthesized and tested as anti-inflammatory agents. Log P values were theoretically calculated and experimentally determined. These compounds were tested for antioxidant activity, as hydroxyl radical scavengers and for their ability to interact with stable 1,1-diphenyl-2-picryl hydrazyl free radical (DPPH). The effect of the synthesized compounds on inflammation, using the carrageenin induced mice paw edema model was studied. Both anti-inflammatory and antioxidant activities depended on some structural characteristics of the synthesized compounds.
Keywords: Thiazolyl amides; anti-inflammatories; antioxidants; lipoxygenase inhibitors Thiazolyl amides; anti-inflammatories; antioxidants; lipoxygenase inhibitors
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Geronikaki, A.; Hadjipavlou-Litina, D.; Chatziopoulos, C.; Soloupis, G. Synthesis and Biological Evaluation of New 4,5-Disubstituted-Thiazolyl Amides, Derivatives of 4-Hydroxy-Piperidine or of 4-N-Methyl Piperazine. Molecules 2003, 8, 472-479.

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