Next Article in Journal / Special Issue
Synthesis of New Polyfused Heterocycles of Biological Importance by Means of Pd(0) Catalysis
Previous Article in Journal / Special Issue
Solid-Phase Synthesis of Methyl N-(pyrimidin-2-yl)glycinate
Article Menu

Export Article

Open AccessArticle
Molecules 2003, 8(6), 472-479; https://doi.org/10.3390/80600472

Synthesis and Biological Evaluation of New 4,5-Disubstituted-Thiazolyl Amides, Derivatives of 4-Hydroxy-Piperidine or of 4-N-Methyl Piperazine

Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotelian University of Thessaloniki, Thessaloniki 54124, Greece
*
Author to whom correspondence should be addressed.
Received: 13 May 2003 / Revised: 15 May 2003 / Accepted: 16 May 2003 / Published: 30 June 2003
Full-Text   |   PDF [303 KB, uploaded 18 June 2014]   |  

Abstract

4,5-disubstituted-thizolyl amides, derivatives of 4-hydroxy-piperidine and of 4-N-methyl piperazine, were synthesized and tested as anti-inflammatory agents. Log P values were theoretically calculated and experimentally determined. These compounds were tested for antioxidant activity, as hydroxyl radical scavengers and for their ability to interact with stable 1,1-diphenyl-2-picryl hydrazyl free radical (DPPH). The effect of the synthesized compounds on inflammation, using the carrageenin induced mice paw edema model was studied. Both anti-inflammatory and antioxidant activities depended on some structural characteristics of the synthesized compounds. View Full-Text
Keywords: Thiazolyl amides; anti-inflammatories; antioxidants; lipoxygenase inhibitors Thiazolyl amides; anti-inflammatories; antioxidants; lipoxygenase inhibitors
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Geronikaki, A.; Hadjipavlou-Litina, D.; Chatziopoulos, C.; Soloupis, G. Synthesis and Biological Evaluation of New 4,5-Disubstituted-Thiazolyl Amides, Derivatives of 4-Hydroxy-Piperidine or of 4-N-Methyl Piperazine. Molecules 2003, 8, 472-479.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top