Molecules 2003, 8(6), 472-479; doi:10.3390/80600472
Article

Synthesis and Biological Evaluation of New 4,5-Disubstituted-Thiazolyl Amides, Derivatives of 4-Hydroxy-Piperidine or of 4-N-Methyl Piperazine

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Received: 13 May 2003; in revised form: 15 May 2003 / Accepted: 16 May 2003 / Published: 30 June 2003
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: 4,5-disubstituted-thizolyl amides, derivatives of 4-hydroxy-piperidine and of 4-N-methyl piperazine, were synthesized and tested as anti-inflammatory agents. Log P values were theoretically calculated and experimentally determined. These compounds were tested for antioxidant activity, as hydroxyl radical scavengers and for their ability to interact with stable 1,1-diphenyl-2-picryl hydrazyl free radical (DPPH). The effect of the synthesized compounds on inflammation, using the carrageenin induced mice paw edema model was studied. Both anti-inflammatory and antioxidant activities depended on some structural characteristics of the synthesized compounds.
Keywords: Thiazolyl amides; anti-inflammatories; antioxidants; lipoxygenase inhibitors
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MDPI and ACS Style

Geronikaki, A.; Hadjipavlou-Litina, D.; Chatziopoulos, C.; Soloupis, G. Synthesis and Biological Evaluation of New 4,5-Disubstituted-Thiazolyl Amides, Derivatives of 4-Hydroxy-Piperidine or of 4-N-Methyl Piperazine. Molecules 2003, 8, 472-479.

AMA Style

Geronikaki A, Hadjipavlou-Litina D, Chatziopoulos C, Soloupis G. Synthesis and Biological Evaluation of New 4,5-Disubstituted-Thiazolyl Amides, Derivatives of 4-Hydroxy-Piperidine or of 4-N-Methyl Piperazine. Molecules. 2003; 8(6):472-479.

Chicago/Turabian Style

Geronikaki, A.; Hadjipavlou-Litina, D.; Chatziopoulos, C.; Soloupis, G. 2003. "Synthesis and Biological Evaluation of New 4,5-Disubstituted-Thiazolyl Amides, Derivatives of 4-Hydroxy-Piperidine or of 4-N-Methyl Piperazine." Molecules 8, no. 6: 472-479.

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