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Special Issue "Selected Papers from the Second Eurasian Meeting on Heterocyclic Chemistry: Heterocycles in Organic and Combinatorial Chemistry"

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A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: closed (13 May 2003)

Special Issue Editor

Guest Editor
Prof. Dr. Eugene Babaev (Website)

Chemistry Department, Moscow State University, GSP-3, Moscow 119991, Russia
Interests: heterocyclic chemistry; periodic table

Special Issue Information

n/a

Keywords

Selected Papers from the Second Eurasian Meeting on Heterocyclic Chemistry: Heterocycles in Organic and Combinatorial Chemistry

Published Papers (8 papers)

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Editorial

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Open AccessEditorial Special Issue: Selected Papers from the Second Eurasian Meeting on Heterocyclic Chemistry: Heterocycles in Organic and Combinatorial Chemistry
Molecules 2003, 8(6), 459; doi:10.3390/80600459
Published: 30 June 2003
Cited by 1 | PDF Full-text (23 KB) | HTML Full-text | XML Full-text

Research

Jump to: Editorial

Open AccessArticle Synthesis of 6-Nitroderivatives of Oxazolo[3,2-a]-pyridines and Their Reactions with Nucleophiles
Molecules 2003, 8(6), 460-466; doi:10.3390/80600460
Received: 13 May 2003 / Revised: 17 June 2003 / Accepted: 17 June 2003 / Published: 30 June 2003
Cited by 4 | PDF Full-text (129 KB)
Abstract
5-Nitro-2-pyridone can be selectively N-phenacylated, and the resulting phenacylpyridones I undergo cyclization to 6-nitrooxazolo[3,2-a]pyridinium salts II. These salts II readily react with ammonia and aliphatic amines leading to the products of pyridine ring opening - previously unknown 1-amino-2-nitro-4-(oxazole-2-yl)butadienes-1,3. Reaction of salts II [...] Read more.
5-Nitro-2-pyridone can be selectively N-phenacylated, and the resulting phenacylpyridones I undergo cyclization to 6-nitrooxazolo[3,2-a]pyridinium salts II. These salts II readily react with ammonia and aliphatic amines leading to the products of pyridine ring opening - previously unknown 1-amino-2-nitro-4-(oxazole-2-yl)butadienes-1,3. Reaction of salts II with water lead to hydrolytic cleavage of the oxazole fragment. Full article
Open AccessArticle Solid-Phase Synthesis of Methyl N-(pyrimidin-2-yl)glycinate
Molecules 2003, 8(6), 467-471; doi:10.3390/80600467
Received: 13 May 2003 / Revised: 17 June 2003 / Accepted: 17 June 2003 / Published: 30 June 2003
Cited by 3 | PDF Full-text (109 KB) | HTML Full-text | XML Full-text
Abstract A versatile method for the preparation of N-heteroaryl substituted aminoacid derivatives is suggested. The method avoids facile diketopiperazine formation. Full article
Open AccessArticle Synthesis and Biological Evaluation of New 4,5-Disubstituted-Thiazolyl Amides, Derivatives of 4-Hydroxy-Piperidine or of 4-N-Methyl Piperazine
Molecules 2003, 8(6), 472-479; doi:10.3390/80600472
Received: 13 May 2003 / Revised: 15 May 2003 / Accepted: 16 May 2003 / Published: 30 June 2003
Cited by 12 | PDF Full-text (303 KB) | HTML Full-text | XML Full-text
Abstract
4,5-disubstituted-thizolyl amides, derivatives of 4-hydroxy-piperidine and of 4-N-methyl piperazine, were synthesized and tested as anti-inflammatory agents. Log P values were theoretically calculated and experimentally determined. These compounds were tested for antioxidant activity, as hydroxyl radical scavengers and for their ability to interact [...] Read more.
4,5-disubstituted-thizolyl amides, derivatives of 4-hydroxy-piperidine and of 4-N-methyl piperazine, were synthesized and tested as anti-inflammatory agents. Log P values were theoretically calculated and experimentally determined. These compounds were tested for antioxidant activity, as hydroxyl radical scavengers and for their ability to interact with stable 1,1-diphenyl-2-picryl hydrazyl free radical (DPPH). The effect of the synthesized compounds on inflammation, using the carrageenin induced mice paw edema model was studied. Both anti-inflammatory and antioxidant activities depended on some structural characteristics of the synthesized compounds. Full article
Open AccessArticle Synthesis of New Polyfused Heterocycles of Biological Importance by Means of Pd(0) Catalysis
Molecules 2003, 8(6), 480-487; doi:10.3390/80600480
Received: 13 May 2003 / Revised: 20 May 2003 / Accepted: 21 May 2003 / Published: 30 June 2003
Cited by 6 | PDF Full-text (149 KB) | HTML Full-text | XML Full-text
Abstract A general synthetic methodology employing heteroaryl-aryl Suzuki coupling is reviewed, by which 15 heteroaromatic ring systems of biological interest have been prepared. Full article
Open AccessArticle Novel Heteroatom-containing Vitamin D3 Analogs: Efficient Synthesis of 1α,25-Dihydroxyvitamin D3-26,23-lactam
Molecules 2003, 8(6), 488-499; doi:10.3390/80600488
Received: 13 May 2003 / Revised: 20 May 2003 / Accepted: 21 May 2003 / Published: 30 June 2003
Cited by 7 | PDF Full-text (209 KB) | HTML Full-text | XML Full-text
Abstract
Vitamin D3 and its synthetic analogs are promising compounds for controlling various types of cell differentiation. In this article, we describe the synthesis of novel vitamin D3 analogs containing heteroatoms in their side chains – so-called vitamin D3 lactam analogs [...] Read more.
Vitamin D3 and its synthetic analogs are promising compounds for controlling various types of cell differentiation. In this article, we describe the synthesis of novel vitamin D3 analogs containing heteroatoms in their side chains – so-called vitamin D3 lactam analogs – via 1,3-dipolar cycloaddition reaction as a key step. Full article
Open AccessArticle The Ring Transformation of 3-Methyl-5-nitropyrimidin-4(3H)-one
Molecules 2003, 8(6), 500-504; doi:10.3390/80600500
Received: 13 May 2003 / Accepted: 15 May 2003 / Published: 30 June 2003
Cited by 2 | PDF Full-text (62 KB) | HTML Full-text | XML Full-text
Abstract 3-Methyl-5-nitropyrimidin-4(3H)-one readily reacts with carbonyl compounds to produce three kinds of ring transformations. The nitropyrimidinone behaves as the synthetic equivalent of activated diformylamine affording 3,5-difunctionalized 4-pyridones, 4,5-disubstituted pyrimidines and functionalized 4-aminopyridines. It also behaves like α-nitro-formylacetic acid to give 5,6-disubstituted 3-nitro-2-pyridones. Full article
Open AccessArticle New Synthetic Approaches to Multifunctional Phenazinium Salt Derivatives
Molecules 2003, 8(6), 505-519; doi:10.3390/80600505
Received: 13 May 2003 / Accepted: 25 June 2003 / Published: 30 June 2003
PDF Full-text (347 KB) | HTML Full-text | XML Full-text
Abstract
Two different approaches are offered for the synthesis under mild conditions of disubstituted phenazinium and benzo[a]phenazinium salts. Direct nucleophilic substitutions by primary and secondary amines in quaternary phenazinium salts containing an additional positive charge in the aliphatic part of the molecule were [...] Read more.
Two different approaches are offered for the synthesis under mild conditions of disubstituted phenazinium and benzo[a]phenazinium salts. Direct nucleophilic substitutions by primary and secondary amines in quaternary phenazinium salts containing an additional positive charge in the aliphatic part of the molecule were carried out. The substitution proceeds successively in positions 2 and 7, which allows selective introduction of different substituents into the heterocycle. Direct nucleophilic substitution in quaternary 2-N-alkyl-acetamidophenazinium and 5-alkoxy-benzo[a]phenazinium salts with different amines can also serve as a convenient method for the introduction of two different substituents. Full article

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