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Special Issue "Selected Papers from the Second Eurasian Meeting on Heterocyclic Chemistry: Heterocycles in Organic and Combinatorial Chemistry"

A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: closed (13 May 2003)

Special Issue Editor

Special Issue Information

Keywords

Published Papers (8 papers)

Eugene V. Babaev Editorial: Special Issue: Selected Papers from the Second Eurasian Meeting on Heterocyclic Chemistry: Heterocycles in Organic and Combinatorial Chemistry Molecules 2003, 8(6), 459; doi:10.3390/80600459 Published: 30 June 2003 Show/Hide Abstract | Download PDF Full-text (23 KB) Abstract: n/a

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Alexander A. Bush and Eugene V. Babaev Article: Synthesis of 6-Nitroderivatives of Oxazolo[3,2-a]-pyridines and Their Reactions with Nucleophiles Molecules 2003, 8(6), 460-466; doi:10.3390/80600460 Received: 13 May 2003; in revised form: 17 June 2003 / Accepted: 17 June 2003 / Published: 30 June 2003 Show/Hide Abstract | Download PDF Full-text (129 KB) Abstract: 5-Nitro-2-pyridone can be selectively N-phenacylated, and the resulting phenacylpyridones I undergo cyclization to 6-nitrooxazolo[3,2-a]pyridinium salts II. These salts II readily react with ammonia and aliphatic amines leading to the products of pyridine ring opening - previously unknown 1-amino-2-nitro-4-(oxazole-2-yl)butadienes-1,3. Reaction of salts II with water lead to hydrolytic cleavage of the oxazole fragment.

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Denis S. Ermolat'ev and Eugene V. Babaev Article: Solid-Phase Synthesis of Methyl N-(pyrimidin-2-yl)glycinate Molecules 2003, 8(6), 467-471; doi:10.3390/80600467 Received: 13 May 2003; in revised form: 17 June 2003 / Accepted: 17 June 2003 / Published: 30 June 2003 Show/Hide Abstract | Download PDF Full-text (109 KB) Abstract: A versatile method for the preparation of N-heteroaryl substituted aminoacid derivatives is suggested. The method avoids facile diketopiperazine formation.

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A. Geronikaki, D. Hadjipavlou-Litina, C. Chatziopoulos and G. Soloupis Article: Synthesis and Biological Evaluation of New 4,5-Disubstituted-Thiazolyl Amides, Derivatives of 4-Hydroxy-Piperidine or of 4-N-Methyl Piperazine Molecules 2003, 8(6), 472-479; doi:10.3390/80600472 Received: 13 May 2003; in revised form: 15 May 2003 / Accepted: 16 May 2003 / Published: 30 June 2003 Show/Hide Abstract | Download PDF Full-text (303 KB) Abstract: 4,5-disubstituted-thizolyl amides, derivatives of 4-hydroxy-piperidine and of 4-N-methyl piperazine, were synthesized and tested as anti-inflammatory agents. Log P values were theoretically calculated and experimentally determined. These compounds were tested for antioxidant activity, as hydroxyl radical scavengers and for their ability to interact with stable 1,1-diphenyl-2-picryl hydrazyl free radical (DPPH). The effect of the synthesized compounds on inflammation, using the carrageenin induced mice paw edema model was studied. Both anti-inflammatory and antioxidant activities depended on some structural characteristics of the synthesized compounds.

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Gy. Hajós, Zs. Riedl, G. Timári, P. Mátyus, B. U. W. Maes and G. L. F. Lemière Article: Synthesis of New Polyfused Heterocycles of Biological Importance by Means of Pd(0) Catalysis Molecules 2003, 8(6), 480-487; doi:10.3390/80600480 Received: 13 May 2003; in revised form: 20 May 2003 / Accepted: 21 May 2003 / Published: 30 June 2003 Show/Hide Abstract | Download PDF Full-text (149 KB) Abstract: A general synthetic methodology employing heteroaryl-aryl Suzuki coupling is reviewed, by which 15 heteroaromatic ring systems of biological interest have been prepared.

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Yuko Kato, Yuichi Hashimoto and Kazuo Nagasawa Article: Novel Heteroatom-containing Vitamin D3 Analogs: Efficient Synthesis of 1α,25-Dihydroxyvitamin D3-26,23-lactam Molecules 2003, 8(6), 488-499; doi:10.3390/80600488 Received: 13 May 2003; in revised form: 20 May 2003 / Accepted: 21 May 2003 / Published: 30 June 2003 Show/Hide Abstract | Download PDF Full-text (209 KB) Abstract: Vitamin D3 and its synthetic analogs are promising compounds for controlling various types of cell differentiation. In this article, we describe the synthesis of novel vitamin D3 analogs containing heteroatoms in their side chains – so-called vitamin D3 lactam analogs – via 1,3-dipolar cycloaddition reaction as a key step.

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Nagatoshi Nishiwaki, Mina Tamura, Kazushige Hori, Yasuo Tohda and Masahiro Ariga Article: The Ring Transformation of 3-Methyl-5-nitropyrimidin-4(3H)-one Molecules 2003, 8(6), 500-504; doi:10.3390/80600500 Received: 13 May 2003 / Accepted: 15 May 2003 / Published: 30 June 2003 Show/Hide Abstract | Download PDF Full-text (62 KB) Abstract: 3-Methyl-5-nitropyrimidin-4(3H)-one readily reacts with carbonyl compounds to produce three kinds of ring transformations. The nitropyrimidinone behaves as the synthetic equivalent of activated diformylamine affording 3,5-difunctionalized 4-pyridones, 4,5-disubstituted pyrimidines and functionalized 4-aminopyridines. It also behaves like α-nitro-formylacetic acid to give 5,6-disubstituted 3-nitro-2-pyridones.

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Inna Yu. Garipova and Vladimir N. Silnikov Article: New Synthetic Approaches to Multifunctional Phenazinium Salt Derivatives Molecules 2003, 8(6), 505-519; doi:10.3390/80600505 Received: 13 May 2003 / Accepted: 25 June 2003 / Published: 30 June 2003 Show/Hide Abstract | Download PDF Full-text (347 KB) Abstract: Two different approaches are offered for the synthesis under mild conditions of disubstituted phenazinium and benzo[a]phenazinium salts. Direct nucleophilic substitutions by primary and secondary amines in quaternary phenazinium salts containing an additional positive charge in the aliphatic part of the molecule were carried out. The substitution proceeds successively in positions 2 and 7, which allows selective introduction of different substituents into the heterocycle. Direct nucleophilic substitution in quaternary 2-N-alkyl-acetamidophenazinium and 5-alkoxy-benzo[a]phenazinium salts with different amines can also serve as a convenient method for the introduction of two different substituents.

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Last update: 29 September 2008