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Molecules 2002, 7(12), 871-884; doi:10.3390/71200871
Article

Synthesis of Some New bis-(p-Fluorophenyl)amides of the Thieno[3,2-b]thiophene, Thieno[3,2-b]furan and 1,2-bis{5-[2-(2-Thienyl)ethenyl]2-thienyl}ethene Series

1, 1, 1 and 2,*
1 "Pliva" d.d., Research and Development, Prilaz baruna Filipovica 25, 10000 Zagreb, Croatia 2 Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulicev trg 20, 10000 Zagreb, Croatia
* Author to whom correspondence should be addressed.
Received: 13 August 2002 / Revised: 28 November 2002 / Accepted: 4 December 2002 / Published: 31 December 2002
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Abstract

Three new heterocyclic substituted dianilides, namely 3-chloro-5-[1-(pfluorophenylcarbamoyl)-2-(2-thienyl)ethenyl]thieno-[3,2-b]thiophene-2-carboxy-p-fluoroanilide (8), 1,2-bis{5-[2-(p-fluorophenylcarbamoyl)-2-(2-thienyl)ethenyl]-2-thienyl}ethene (13) and 6-chloro-2-{2-[3-chloro-2-(p-fluorophenyl-carbamoyl)-5-thieno[3,2-b]thienyl]-2-ethoxycarbonylethenyl}thieno[3,2-b]furan-5-carboxy-p-fluoroanilide (20) were prepared by multistep synthesis. The prepared dianilides are of particular interest for their potential to serve as the planar heteroaromatic core of DNA intercalators or groove binders.
Keywords: Amides; thieno[3; 2-b]thienyl- series; potential intercalators or groove binders Amides; thieno[3; 2-b]thienyl- series; potential intercalators or groove binders
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Pavlicic, D.; Koružnjak, J.D.; Banic-Tomišic, Z.; Karminski-Zamola, G. Synthesis of Some New bis-(p-Fluorophenyl)amides of the Thieno[3,2-b]thiophene, Thieno[3,2-b]furan and 1,2-bis{5-[2-(2-Thienyl)ethenyl]2-thienyl}ethene Series. Molecules 2002, 7, 871-884.

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