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Molecules 2002, 7(12), 871-884; doi:10.3390/71200871
Article

Synthesis of Some New bis-(p-Fluorophenyl)amides of the Thieno[3,2-b]thiophene, Thieno[3,2-b]furan and 1,2-bis{5-[2-(2-Thienyl)ethenyl]2-thienyl}ethene Series

1, 1, 1 and 2,*
Received: 13 August 2002 / Revised: 28 November 2002 / Accepted: 4 December 2002 / Published: 31 December 2002
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Abstract

Three new heterocyclic substituted dianilides, namely 3-chloro-5-[1-(pfluorophenylcarbamoyl)-2-(2-thienyl)ethenyl]thieno-[3,2-b]thiophene-2-carboxy-p-fluoroanilide (8), 1,2-bis{5-[2-(p-fluorophenylcarbamoyl)-2-(2-thienyl)ethenyl]-2-thienyl}ethene (13) and 6-chloro-2-{2-[3-chloro-2-(p-fluorophenyl-carbamoyl)-5-thieno[3,2-b]thienyl]-2-ethoxycarbonylethenyl}thieno[3,2-b]furan-5-carboxy-p-fluoroanilide (20) were prepared by multistep synthesis. The prepared dianilides are of particular interest for their potential to serve as the planar heteroaromatic core of DNA intercalators or groove binders.
Keywords: Amides; thieno[3; 2-b]thienyl- series; potential intercalators or groove binders Amides; thieno[3; 2-b]thienyl- series; potential intercalators or groove binders
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Pavlicic, D.; Koružnjak, J.D.; Banic-Tomišic, Z.; Karminski-Zamola, G. Synthesis of Some New bis-(p-Fluorophenyl)amides of the Thieno[3,2-b]thiophene, Thieno[3,2-b]furan and 1,2-bis{5-[2-(2-Thienyl)ethenyl]2-thienyl}ethene Series. Molecules 2002, 7, 871-884.

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