Next Article in Journal
Determination of Aldehyde Dehydrogenase (ALDH) Isozymes in Human Cancer Samples - Comparison of Kinetic and Immunochemical Assays
Previous Article in Journal
Synthesis of Some New bis-(p-Fluorophenyl)amides of the Thieno[3,2-b]thiophene, Thieno[3,2-b]furan and 1,2-bis{5-[2-(2-Thienyl)ethenyl]2-thienyl}ethene Series
Article Menu

Export Article

Correction published on 12 May 2006, see Molecules 2006, 11(5), 370.

Open AccessArticle
Molecules 2002, 7(12), 885-895; doi:10.3390/71200885

Synthesis and Characterization of New 3,5-Dinaphthyl Substituted 2-Pyrazolines and Study of Their Antimicrobial Activity

Department of Chemistry, Faculty of Science, Bu-Ali Sina University, Zip Code 65174, Hamadan, Iran
*
Author to whom correspondence should be addressed.
Received: 12 March 2002 / Revised: 15 November 2002 / Accepted: 17 November 2002 / Published: 31 December 2002
View Full-Text   |   Download PDF [397 KB, uploaded 18 June 2014]   |  

Abstract

A number of chalcones were prepared by condensing either 1-acetylnaphthalene or substituted 1-acetylnaphthalenes with 1-naphthaldehyde or 4-dimethylamino-1-naphthaldehyde in ethanolic NaOH solutions. These chalcones were immediately reacted with hydrazine hydrochloride, phenyl hydrazine and semicarbazide hydrochloride in the presence of dry acetic acid to obtain the corresponding 2-pyrazolines. The synthesised heterocycles were characterized on the basis of their chemical properties and spectroscopic data. These compounds were tested for antimicrobial activity against a variety of test organisms: Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Proteus mirabillis, Shigella dysentry and Salmonella typhii. The compounds containing chloro, hydroxo and dimethylamino - N(CH3)2 group as substituents on the naphthalene rings have been found to be very effective antimicrobial agents. In addition, the presence of a carboxamido -CONH2 substituent group at the N-1 position of the 2-pyrazoline rings is shown to contribute substantially to the antimicrobial activity. View Full-Text
Keywords: Chalcones; (Naphthalene-/substituted naphthalene-1-yl)-2-pyrazolines; Aryl substituted pyrazolines; Pyrazolines; Antimicrobial activity; Heterocyclics Chalcones; (Naphthalene-/substituted naphthalene-1-yl)-2-pyrazolines; Aryl substituted pyrazolines; Pyrazolines; Antimicrobial activity; Heterocyclics
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Azarifar, D.; Shaebanzadeh, M. Synthesis and Characterization of New 3,5-Dinaphthyl Substituted 2-Pyrazolines and Study of Their Antimicrobial Activity. Molecules 2002, 7, 885-895.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top