Molecules 1999, 4(10), 287-309; doi:10.3390/41000287

Synthesis of N-7-Substituted Purines from Imidazole Precursors

Received: 23 February 1999; Accepted: 4 June 1999 / Published: 25 September 1999
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Synthesis of purines and purine mono-1-oxides from the respective 5-substituted 4-nitroimidazole derivatives is described. The commercially available 4-nitroimidazole, in a few simple steps (including Vicarious Nucleophilic Substitution of Hydrogen), was transformed into: 4-aminoimidazoyl-5-carboximes, N-[1-(4-amino-1H-imidazol-5-yl)methylidene]-N-(aryl)amine derivatives or into 4-amino-5-aminomethyl-imidazole. These intermediates were cyclized to the final products.
Keywords: purines; purine N-oxides; nitroimidazoles; oximes; Schiff bases; isocyanides; Vicarious Nucleophilic Substitution
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MDPI and ACS Style

Ostrowski, S. Synthesis of N-7-Substituted Purines from Imidazole Precursors. Molecules 1999, 4, 287-309.

AMA Style

Ostrowski S. Synthesis of N-7-Substituted Purines from Imidazole Precursors. Molecules. 1999; 4(10):287-309.

Chicago/Turabian Style

Ostrowski, Stanislaw. 1999. "Synthesis of N-7-Substituted Purines from Imidazole Precursors." Molecules 4, no. 10: 287-309.

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