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Molecules 1999, 4(10), 279-286; doi:10.3390/41000279
Article

Synthetical Application of Alkyl 2-isothiocyanatocarboxylates. A Simple Synthesis of 5-Substituted-3-amino-2-thioxo-4-imidazolidinones (3-Amino-2-thiohydantoins)

1,* , 2 and 1
1 Department of Organic Chemistry, Faculty of Chemical Technology, Slovak University of Technology, Radlinskeho 9, SK-812 37 Bratislava, Slovak Republic 2 Drug Research Institute, SK- 900 01 Modra, Slovak Republic
* Author to whom correspondence should be addressed.
Received: 20 August 1999 / Accepted: 7 September 1999 / Published: 22 September 1999
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Abstract

The title 3-amino-2-thiohydantoins 3 has been prepared in very good yields by the reaction of alkyl isothiocynatocarboxylates 1 with hydrazine hydrate.The synthesis of starting isothiocyanates as well as spectral data of 3-aminothiohydantoins and alkyl isothiocyanatocarboxylates has been presented.
Keywords: thiohydantoin; isothiocyanate; thiosemicarbazide; agrochemicals thiohydantoin; isothiocyanate; thiosemicarbazide; agrochemicals
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Floch, L.; Oremus, V.; Kovac, M. Synthetical Application of Alkyl 2-isothiocyanatocarboxylates. A Simple Synthesis of 5-Substituted-3-amino-2-thioxo-4-imidazolidinones (3-Amino-2-thiohydantoins). Molecules 1999, 4, 279-286.

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