Display options:
Normal
Show Abstracts
Compact
Select/unselect all
Displaying article 1-8
M43
Received: 22 December 1997 / Published: 25 January 1998
Show/Hide Abstract
| Download PDF Full-text (96 KB) | Abstract: n/a
M44
Received: 22 December 1997 / Published: 25 January 1998
Show/Hide Abstract
| Download PDF Full-text (76 KB) | Abstract: n/a
M45
Received: 22 December 1997 / Published: 25 January 1998
Show/Hide Abstract
| Download PDF Full-text (85 KB) | Abstract: n/a
p. 1-9
Received: 29 October 1997 / Accepted: 8 December 1997 / Published: 25 January 1998
Show/Hide Abstract
| Download PDF Full-text (272 KB) Abstract: Recent results from the author's laboratory in the area of dihydropyrimidine chemistry are summarized.
p. 10-15
Received: 15 October 1997 / Accepted: 19 November 1997 / Published: 25 January 1998
Show/Hide Abstract
| Download PDF Full-text (150 KB) Abstract: The preparation of a series of new 3-(alkynyl-X)-substituted 4-pyridazinecarbonitriles 2-5 (X = O, NH) is described. The compounds are shown to undergo thermally induced intramolecular Diels-Alder reactions with inverse electron demand, affording the fused benzonitriles 6-8. Incorporation of a 1,2-phenylene unit into the side chain, as in the case of compounds 10 and 13, results in a more favorable conformation of the dienophilic substructure and thus to a pronounced acceleration of the [4+2] cycloaddition reaction.
p. 16-19
Received: 12 December 1997 / Accepted: 14 January 1998 / Published: 25 January 1999
Show/Hide Abstract
| Download PDF Full-text (136 KB) Abstract: This review describes the history of the "Molecule of the Month" Website, along with a short summary of some of the molecules which featured during 1997.
p. 20-25
Received: 11 November 1997 / Accepted: 15 January 1998 / Published: 25 January 1998
Show/Hide Abstract
| Download PDF Full-text (45 KB) Abstract: The synthesis and biological evaluation of 14β-methoxy derivatives of digitoxigenin and of other digitalis-like compounds are reported. These compounds have a 14β-oxygen, which can be a hydrogen bonding acceptor, as is the case of 14β,15β-epoxide derivatives, but not a hydrogen bonding donor as is the case of 14β-hydroxy derivatives. All the new 14β-methoxy derivatives show a considerable reduced binding affinity on Na+ ,K+ -ATPase when compared with the 14β-hydroxy analogues and also with the 14β,15β-epoxy derivatives. These results could mean that the digitalis receptor does not permit the presence of a bulky substituent in the 14β region, even of relatively small volume like the methyl group
p. 26-30
Received: 1 October 1997 / Accepted: 15 January 1998 / Published: 25 January 1998
Show/Hide Abstract
| Download PDF Full-text (28 KB) Abstract: The nucleophilic addition of 2-furyllithium to esters derived from L-serine is described. The obtained furyl ketone 5 is stereoselectively reduced (ds≥95%) with sodium borohydride to afford the corresponding syn aminoalcohol 12 in enantiomerically pure form. Compound 12 was further converted into valuable α-hydroxy-β-amino acids by means of the furan-to-acid equivalence.
Select/unselect all
Displaying article 1-8
Export citation of selected articles as:
Plain Text
BibTeX
BibTeX (without abstracts)
Endnote
Endnote (without abstracts)
Tab-delimited
PubMed XML
DOAJ XML
AGRIS XML