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Molecules 2018, 23(8), 2011; https://doi.org/10.3390/molecules23082011

Novel 3-Methyl-2-alkylthio Benzothiazolyl-Based Ionic Liquids: Synthesis, Characterization, and Antibiotic Activity

1
School of Chemical Engineering, Sichuan University, Chengdu 610065, China
2
Mianyang Blood Center, Mianyang 621000, China
3
College of Chemistry and Chemical Engineering, Mianyang Normal University, Mianyang 621000, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 23 July 2018 / Revised: 6 August 2018 / Accepted: 6 August 2018 / Published: 12 August 2018
(This article belongs to the Special Issue Ionic Liquids for Chemical and Biochemical Applications)
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Abstract

Three series of novel 3-methyl-2-alkylthio benzothiazolyl ionic liquids (ILs) were synthesized for the first time. After structural identification, their melting point, solubility, and thermostability together with antibiotic activity were determined successively. As a result, 3-methyl-2-alkylthio benzothiazolyl p-toluene sulfonate was found to have the highest antibacterial activity among the three series of ILs. Meanwhile, it has a good solubility in water as well. On the basis of comprehensive comparison with similar compounds, the effect of cations and anions of these benzothiazolium ILs on typical physical properties together with antibiotic performance was explored and discussed, which is very beneficial to take the greatest advantage of their structural designability for various purposes. Furthermore, the experiment data preliminarily discovered the relationships of the structure-properties/activities of the above three kinds ILs to a certain extent, which can provide useful references for future research and for the potential application of these new ILs as surfactant antiseptics or agricultural chemicals. View Full-Text
Keywords: 3-methyl-2-alkylthio benzothiazolyl-based ionic liquids; solubility; thermal stability; antibiotic activity 3-methyl-2-alkylthio benzothiazolyl-based ionic liquids; solubility; thermal stability; antibiotic activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zhang, T.H.; He, H.X.; Du, J.L.; He, Z.J.; Yao, S. Novel 3-Methyl-2-alkylthio Benzothiazolyl-Based Ionic Liquids: Synthesis, Characterization, and Antibiotic Activity. Molecules 2018, 23, 2011.

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