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Special Issue "Ionic Liquids for Chemical and Biochemical Applications"

A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: 15 August 2018

Special Issue Editor

Guest Editor
Prof. Dr. Yen-Ho Chu

Department of Chemistry and Biochemistry, National Chung Cheng University, 168 University Road, Minhsiung, Chiayi 62102, Taiwan
Website | E-Mail
Phone: 886-5-2428148
Interests: newfangled ionic liquid; combinatorial organic synthesis; affinity ionic liquid; biomolecular recognition; functionalized ionic liquid; chemoselective gas analysis; bioorganic and bioanalytical chemistry

Special Issue Information

Dear Colleagues,

Ionic liquids are well known to be valuable nonvolatile alternatives to conventional organic solvents and have received impressive attention over the past seventeen years (75,059 publications since 2000, based on the Web of Science search dated on 21 January 2018) in all aspects of chemical and biochemical applications.

In 2018, the journal Molecules will be publishing a Special Issue of a collection of papers featuring selected contributions from the “Ionic liquids for Chemical and Biochemical Applications”. As the Guest Editor of this Special Issue, I am writing to you to invite you to contribute a research paper, rapid communication or review article on your current research activities in the area of ionic liquids for targeted molecule analysis.

This Special Issue will be a collection of papers focusing on ionic liquids as smart media for reactions, as well as synthesis, and ionic liquid devices for affinity extraction and analysis. We anticipate this issue will be attractive to the scientific community of synthesis, materials, and separation. This special issue invites contributions covering the aspects broadly indicated by the keywords. Reviews articles by experts are also welcomed.

Prof. Dr. Yen-Ho Chu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • ionic liquid
  • affinity ionic liquid
  • ionic solvent
  • chemical stability
  • organic reaction
  • microwave synthesis
  • isolation and analysis of natural product
  • smart electrolyte device
  • gas sensing
  • affinity extraction
  • chromatographic separation
  • target molecule analysis
  • thermoresponsiveness
  • zwitterionic liquid
  • functional ionic liquid
  • bioactivity
  • enzymatic catalysis
  • DNA, protein, peptide, and carbohydrate
  • (bio)molecular recognition
  • desalination and water treatment
  • polymer dissolution
  • oil extraction

Published Papers (1 paper)

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Open AccessArticle Lipase-Catalyzed Synthesis of Sucrose Monolaurate and Its Antibacterial Property and Mode of Action against Four Pathogenic Bacteria
Molecules 2018, 23(5), 1118; https://doi.org/10.3390/molecules23051118
Received: 26 April 2018 / Revised: 4 May 2018 / Accepted: 7 May 2018 / Published: 8 May 2018
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The aim of this work was to evaluate the antibacterial activities and mode of action of sucrose monolaurate (SML) with a desirable purity, synthesized by Lipozyme TL IM-mediated transesterification in the novel ionic liquid, against four pathogenic bacteria including L. monocytogenes, B. subtilis,
[...] Read more.
The aim of this work was to evaluate the antibacterial activities and mode of action of sucrose monolaurate (SML) with a desirable purity, synthesized by Lipozyme TL IM-mediated transesterification in the novel ionic liquid, against four pathogenic bacteria including L. monocytogenes, B. subtilis, S. aureus, and E. coli. The antibacterial activity was determined by minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and the time–kill assay. SML showed varying antibacterial activity against tested bacteria with MICs and MBCs of 2.5 and 20 mM for L. monocytogenes, 2.5 and 20 mM for B. subtilis, 10 and 40 mM for S. aureus, respectively. No dramatic inhibition was observed for E. coli at 80 mM SML. Mechanism of bacterial inactivation caused by SML was revealed through comprehensive factors including cell morphology, cellular lysis, membrane permeability, K+ leakage, zeta potential, intracellular enzyme, and DNA assay. Results demonstrated that bacterial inactivation against Gram-positive bacteria was primarily induced by the pronounced damage to the cell membrane integrity. SML may interact with cytoplasmic membrane to disturb the regulation system of peptidoglycan hydrolase activities to degrade the peptidoglycan layer and form a hole in the layer. Then, the inside cytoplasmic membrane was blown out due to turgor pressure and the cytoplasmic materials inside leaked out. Leakage of intracellular enzyme to the supernatants implied that the cell membrane permeability was compromised. Consequently, the release of K+ from the cytosol lead to the alterations of the zeta potential of cells, which would disturb the subcellular localization of some proteins, and thereby causing bacterial inactivation. Moreover, remarkable interaction with DNA was also observed. SML at sub-MIC inhibited biofilm formation by these bacteria. Full article
(This article belongs to the Special Issue Ionic Liquids for Chemical and Biochemical Applications)

Figure 1a

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