tert-Butylphenolic Derivatives from Paenibacillus odorifer—A Case of Bioconversion
AbstractTwo compounds (1) and (2) containing tert-butylphenol groups were, for the first time, produced during the culture of Paenibacillus odorifer, a bacterial strain associated with the crustose lichen, Rhizocarpon geographicum. Their entire structures were identified by one-dimensional (1D) and two-dimensional (2D) NMR and high-resolution electrospray ionisation mass spectrometry (HRESIMS) spectroscopic analyses. Among them, Compound 1 exhibited significant cytotoxicity against B16 murine melanoma and HaCaT human keratinocyte cell lines with micromolar half maximal inhibitory concentration (IC50) values. Furthermore, after supplementation studies, a putative biosynthesis pathway was proposed for Compound 1 throughout a bioconversion by this bacterial strain of butylated hydroxyanisole (BHA), an antioxidant polymer additive. View Full-Text
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Nguyen, T.-B.-L.; Delalande, O.; Rouaud, I.; Ferron, S.; Chaillot, L.; Pedeux, R.; Tomasi, S. tert-Butylphenolic Derivatives from Paenibacillus odorifer—A Case of Bioconversion. Molecules 2018, 23, 1951.
Nguyen T-B-L, Delalande O, Rouaud I, Ferron S, Chaillot L, Pedeux R, Tomasi S. tert-Butylphenolic Derivatives from Paenibacillus odorifer—A Case of Bioconversion. Molecules. 2018; 23(8):1951.Chicago/Turabian Style
Nguyen, Thi-Bach-Le; Delalande, Olivier; Rouaud, Isabelle; Ferron, Solenn; Chaillot, Laura; Pedeux, Rémy; Tomasi, Sophie. 2018. "tert-Butylphenolic Derivatives from Paenibacillus odorifer—A Case of Bioconversion." Molecules 23, no. 8: 1951.
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