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Molecules 2018, 23(7), 1727; https://doi.org/10.3390/molecules23071727

Microwave-Assisted Synthesis of Some Potential Bioactive Imidazolium-Based Room-Temperature Ionic Liquids

1
Department of Chemistry, Taibah University, Al-Madina Al-Mounawara 30002, Saudi Arabia
2
Department of Biology Department, Taibah University, Al-Madina Al-Mounawara 30002, Saudi Arabia
3
Microbiology Department, Faculty of Science, Ain Shams University, Cairo 11566, Egypt
4
King Abdulaziz City for Science and Technology, Riyadh 11442, P.O. Box 6086, Saudi Arabia
5
Laboratoire de Chimie & Electrochimie des Complexes Métalliques (LCECM) USTO-MB, University of Sciences and Technology Mohamed Boudiaf, BP 1505 Oran, El M nouar, Algeria
*
Author to whom correspondence should be addressed.
Academic Editor: Yen-Ho Chu
Received: 11 June 2018 / Revised: 12 July 2018 / Accepted: 13 July 2018 / Published: 15 July 2018
(This article belongs to the Special Issue Ionic Liquids for Chemical and Biochemical Applications)
Full-Text   |   PDF [1941 KB, uploaded 15 July 2018]   |  

Abstract

An environmentally-friendly and easy synthesis of a series of novel functionalized imidazolium-based ionic liquids (ILs) is described under both the conventional procedure and microwave irradiation. The structures of newly synthesized room-temperature ionic liquids (RTILs) were established by different spectral analyses. All ILs (114) were screened for their in vitro antimicrobial activity against a panel of clinically isolated bacteria. The results of the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) showed that some of the tested ILs are very promising anti-bacterial agents especially those containing an alkyl chain with a phenyl group (most notably 1, 2, 12, and 13). View Full-Text
Keywords: ionic liquids; imidazolium; green synthesis; microwave irradiation; toxicity; antibacterial activity ionic liquids; imidazolium; green synthesis; microwave irradiation; toxicity; antibacterial activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Albalawi, A.H.; El-Sayed, W.S.; Aljuhani, A.; Almutairi, S.M.; Rezki, N.; Aouad, M.R.; Messali, M. Microwave-Assisted Synthesis of Some Potential Bioactive Imidazolium-Based Room-Temperature Ionic Liquids. Molecules 2018, 23, 1727.

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