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Molecules 2018, 23(7), 1631; https://doi.org/10.3390/molecules23071631

Effects of Blue-Light-Induced Free Radical Formation from Catechin Hydrate on the Inactivation of Acinetobacter baumannii, Including a Carbapenem-Resistant Strain

1
Tea Research and Extension Station, Taoyuan 32654, Taiwan
2
Department of Biotechnology, Ming-Chuan University, Gui-Shan 33343, Taiwan
3
Department of Dermatology, Department of Biochemistry and Molecular Biology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan
4
Division of Infection, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan
5
Department of Science Education and Application, National Taichung University of Education, Taichung 40306, Taiwan
6
Department of Horticulture and Landscape Architecture, National Taiwan University, Taipei 10617, Taiwan
*
Authors to whom correspondence should be addressed.
Academic Editor: Michael R. Hamblin
Received: 14 June 2018 / Revised: 29 June 2018 / Accepted: 2 July 2018 / Published: 4 July 2018
(This article belongs to the Special Issue Advances in Photodynamic Therapy 2018)
View Full-Text   |   Download PDF [2869 KB, uploaded 4 July 2018]   |  

Abstract

Catechin is a flavan-3-ol, a derivative of flavans, with four phenolic hydroxyl groups, which exhibits a wide range of physiological properties. Chromatographic analyses were employed to examine the effects of blue light irradiation on the changes of catechin hydrate in an alkaline condition. In particular, the detection of a superoxide anion radical (O2), a reactive oxygen species (ROS), and the inactivation of Acinetobacter baumannii (A. baumannii)—including a carbapenem-resistant A. baumannii (CRAB)—was investigated during the photoreaction of catechin hydrate. Following basification with blue light irradiation, the transparent solution of catechin hydrate turned yellowish, and a chromogenic catechin dimer was separated and identified as a proanthocyanidin. Adding ascorbic acid during the photolytic treatment of catechin hydrate decreased the dimer formation, suggesting that ascorbic acid can suppress the photosensitive oxidation of catechin. When catechin hydrate was irradiated by blue light in an alkaline solution, O2 was produced via photosensitized oxidation, enhancing the inactivation of A. baumannii and CRAB. The present findings on the photon-induced oxidation of catechin hydrate provides a safe practice for the inactivation of environmental microorganisms. View Full-Text
Keywords: ascorbic acid; blue light; catechin; CRAB; inactivation ascorbic acid; blue light; catechin; CRAB; inactivation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Yang, M.-J.; Hung, Y.-A.; Wong, T.-W.; Lee, N.-Y.; Yuann, J.-M.P.; Huang, S.-T.; Wu, C.-Y.; Chen, I.-Z.; Liang, J.-Y. Effects of Blue-Light-Induced Free Radical Formation from Catechin Hydrate on the Inactivation of Acinetobacter baumannii, Including a Carbapenem-Resistant Strain. Molecules 2018, 23, 1631.

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