Towards an Asymmetric Organocatalytic α-Azidation of β-Ketoesters
AbstractDetailed investigations concerning the organocatalytic (asymmetric) α-azidation of prochiral β-ketoesters were carried out. It was shown that the racemic version of such a reaction can either be carried out under oxidative conditions using TMSN3 as the azide-source with quaternary ammonium iodides as the catalysts, or by using hypervalent iodine-based electrophilic azide-transfer reagents with different organocatalysts. In addition, the latter strategy could also be carried out with modest enantioselectivities when using simple cinchona alkaloid catalysts, albeit with relatively low yields. View Full-Text
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Tiffner, M.; Stockhammer, L.; Schörgenhumer, J.; Röser, K.; Waser, M. Towards an Asymmetric Organocatalytic α-Azidation of β-Ketoesters. Molecules 2018, 23, 1142.
Tiffner M, Stockhammer L, Schörgenhumer J, Röser K, Waser M. Towards an Asymmetric Organocatalytic α-Azidation of β-Ketoesters. Molecules. 2018; 23(5):1142.Chicago/Turabian Style
Tiffner, Maximilian; Stockhammer, Lotte; Schörgenhumer, Johannes; Röser, Katharina; Waser, Mario. 2018. "Towards an Asymmetric Organocatalytic α-Azidation of β-Ketoesters." Molecules 23, no. 5: 1142.
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