Next Article in Journal
Towards an Asymmetric Organocatalytic α-Azidation of β-Ketoesters
Next Article in Special Issue
Antibodies towards Tyrosine Amyloid-Like Fibrils Allow Toxicity Modulation and Cellular Imaging of the Assemblies
Previous Article in Journal
Unprecedented Fluorescent Dinuclear CoII and ZnII Coordination Compounds with a Symmetric Bis(salamo)-Like Tetraoxime
Previous Article in Special Issue
Passive Aβ Immunotherapy: Current Achievements and Future Perspectives
Article Menu
Issue 5 (May) cover image

Export Article

Open AccessReview
Molecules 2018, 23(5), 1143; https://doi.org/10.3390/molecules23051143

Network Medicine for Alzheimer’s Disease and Traditional Chinese Medicine

1
Neurochemistry Laboratory, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
2
Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
*
Author to whom correspondence should be addressed.
Academic Editor: Stephan Schilling
Received: 17 April 2018 / Revised: 7 May 2018 / Accepted: 9 May 2018 / Published: 11 May 2018
(This article belongs to the Special Issue 25th Anniversary of the Amyloid Hypothesis and Alzheimer Disease)
Full-Text   |   PDF [248 KB, uploaded 11 May 2018]   |  

Abstract

Alzheimer’s Disease (AD) is a neurodegenerative condition that currently has no known cure. The principles of the expanding field of network medicine (NM) have recently been applied to AD research. The main principle of NM proposes that diseases are much more complicated than one mutation in one gene, and incorporate different genes, connections between genes, and pathways that may include multiple diseases to create full scale disease networks. AD research findings as a result of the application of NM principles have suggested that functional network connectivity, myelination, myeloid cells, and genes and pathways may play an integral role in AD progression, and may be integral to the search for a cure. Different aspects of the AD pathology could be potential targets for drug therapy to slow down or stop the disease from advancing, but more research is needed to reach definitive conclusions. Additionally, the holistic approaches of network pharmacology in traditional Chinese medicine (TCM) research may be viable options for the AD treatment, and may lead to an effective cure for AD in the future. View Full-Text
Keywords: Alzheimer’s disease; network medicine; inflammation; network and system pharmacology; traditional Chinese medicine Alzheimer’s disease; network medicine; inflammation; network and system pharmacology; traditional Chinese medicine
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Jarrell, J.T.; Gao, L.; Cohen, D.S.; Huang, X. Network Medicine for Alzheimer’s Disease and Traditional Chinese Medicine. Molecules 2018, 23, 1143.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top