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Special Issue "Enantioselective Catalysis"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Synthesis".

Deadline for manuscript submissions: 20 May 2018

Special Issue Editors

Guest Editor
Prof. Dr. Laura Palombi

Dipartimento di Chimica e Biologia, Università di Salerno, Via GiovanniPaolo II, 132, 84084-Fisciano, SA, Italy
Website | E-Mail
Interests: stereoselective synthesis; heterocycles; electrosynthesis; electrocatalysis; organocatalysis
Guest Editor
Prof. Dr. Antonio Massa

Dipartimento di Chimica e Biologia, Università di Salerno, Via Giovanni Paolo II, 132, 84084-Fisciano, SA, Italy
Website | E-Mail
Phone: +39 089 969565
Interests: asymmetric synthesis; synthesis of bioactive compounds; organocatalysis; heterocycles; scale-up and development

Special Issue Information

Dear Colleagues,

Asymmetric Catalysis is one of the most powerful methods for the achievement of optically-active organic compounds, entities with a central role in synthetic, medicinal and material chemistry. Given the continuous advancements in this area and, as a consequence, the new challenges to be faced, a focus on this matter is highly desirable. The main aim of this Special Issue is to highlight strategies, methodologies and techniques recently implemented to promote chiral induction. Original research papers and reviews encompassing the various aspects of asymmetric catalysis, such as the designing of tailored catalysts, development of new catalytic systems, synthetic applications and mechanistic studies dealing with stereo-controlled catalytic reactions are welcome.

Prof. Dr. Laura Palombi
Prof. Dr. Antonio Massa
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Chiral catalysts
  • Stereoselective processes
  • Phase transfer catalysis
  • Organocatalysis

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Type of the paper: Article
Tentative title: General method for the synthesis of (-)-conduritol C and analogs from chiral cyclohexadiendiol scaffolds
Authors: Gaurao D. Tibhe 1, Mario Macías 2,3, Valeria Schapiro 1, Leopoldo Suescun 2, Enrique Pandolfi 1,*
Affiliations: 1 Laboratorio de Síntesis Orgánica, Departamento de Química Orgánica, Facultad de Química, Universidad de la República,, Montevideo, Uruguay
2 Cryssmat-Lab/Cátedra de Física/DETEMA, Facultad de Química, Universidad de la República, Montevideo, Uruguay
3 Departamento de Química, Universidad de los Andes, Carrera 1 No 18A-12, Bogotá, Colombia
*Correspondence: epandolf@fq.edu.uy
Abstract: An efficient and facile general method for the synthesis of conduritol-C analogs, taking advantage of an enantioselective biocatalysis process of mono-substituted benzenes was described. In fact, absolute stereochemical configuration of the targets molecules:  (-)-conduritol-C, bromo-conduritol-C and methyl-conduritol-C was achieved using chemoenzymatic methods. The stereochemistry present at the homochiral cyclohexadiene-cys-1,2-diols derived from the arene biotransformation, and enantioselective  ring opening of a vinylepoxide,derivative, established the absolute configuration of conduritol C hydroxyl groups. All three conduritols and two intermediates were crystallized, and their structures were confirmed from X-ray diffraction data. We would like also to remark that according to our methodology it is possible to expand the number of conduritol C analogs by varying the substituentof the corresponding arene to be biocatalytically transformed.
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