Nine New Gingerols from the Rhizoma of Zingiber officinale and Their Cytotoxic Activities
AbstractNine new gingerols, including three 6-oxo-shogaol derivatives [(Z)-6-oxo--shogaol (1), (Z)-6-oxo--shogaol (2), (Z)-6-oxo--shogaol (3)], one 6-oxoparadol derivative [6-oxo--paradol (4)], one isoshogaol derivative [(E)--isoshogaol (5)], and four paradoldiene derivatives [(4E,6Z)--paradoldiene (8), (4E,6E)--paradoldiene (9), (4E,6E)--paradoldiene (10), (4E,6Z)--paradoldiene (11)], together with eight known analogues, were isolated from the rhizoma of Zingiber officinale. Their structures were elucidated on the basis of spectroscopic data. It was noted that the isolation of 6-oxo-shogaol derivatives represents the first report of gingerols containing one 1,4-enedione motif. Their structures were elucidated on the basis of spectroscopic and HRESIMS data. All the new compounds were evaluated for their cytotoxic activities against human cancer cells (MCF-7, HepG-2, KYSE-150). View Full-Text
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Li, Z.; Wang, Y.; Gao, M.; Cui, W.; Zeng, M.; Cheng, Y.; Li, J. Nine New Gingerols from the Rhizoma of Zingiber officinale and Their Cytotoxic Activities. Molecules 2018, 23, 315.
Li Z, Wang Y, Gao M, Cui W, Zeng M, Cheng Y, Li J. Nine New Gingerols from the Rhizoma of Zingiber officinale and Their Cytotoxic Activities. Molecules. 2018; 23(2):315.Chicago/Turabian Style
Li, Zezhi; Wang, Yanzhi; Gao, MeiLing; Cui, Wanhua; Zeng, Mengnan; Cheng, Yongxian; Li, Juan. 2018. "Nine New Gingerols from the Rhizoma of Zingiber officinale and Their Cytotoxic Activities." Molecules 23, no. 2: 315.
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