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Molecules 2018, 23(2), 315; https://doi.org/10.3390/molecules23020315

Nine New Gingerols from the Rhizoma of Zingiber officinale and Their Cytotoxic Activities

1
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
2
Collaborative Innovation Center for Respiratory Disease Diagnosis, Treatment and New Drug Research and Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, China
3
Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, School of Medicine, Shenzhen University Health Science Center, Shenzhen 518060, China
*
Author to whom correspondence should be addressed.
Received: 9 December 2017 / Revised: 30 January 2018 / Accepted: 31 January 2018 / Published: 2 February 2018
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Abstract

Nine new gingerols, including three 6-oxo-shogaol derivatives [(Z)-6-oxo-[6]-shogaol (1), (Z)-6-oxo-[8]-shogaol (2), (Z)-6-oxo-[10]-shogaol (3)], one 6-oxoparadol derivative [6-oxo-[6]-paradol (4)], one isoshogaol derivative [(E)-[4]-isoshogaol (5)], and four paradoldiene derivatives [(4E,6Z)-[4]-paradoldiene (8), (4E,6E)-[6]-paradoldiene (9), (4E,6E)-[8]-paradoldiene (10), (4E,6Z)-[8]-paradoldiene (11)], together with eight known analogues, were isolated from the rhizoma of Zingiber officinale. Their structures were elucidated on the basis of spectroscopic data. It was noted that the isolation of 6-oxo-shogaol derivatives represents the first report of gingerols containing one 1,4-enedione motif. Their structures were elucidated on the basis of spectroscopic and HRESIMS data. All the new compounds were evaluated for their cytotoxic activities against human cancer cells (MCF-7, HepG-2, KYSE-150). View Full-Text
Keywords: Zingiber officinale; gingerols; cytotoxic activity Zingiber officinale; gingerols; cytotoxic activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Li, Z.; Wang, Y.; Gao, M.; Cui, W.; Zeng, M.; Cheng, Y.; Li, J. Nine New Gingerols from the Rhizoma of Zingiber officinale and Their Cytotoxic Activities. Molecules 2018, 23, 315.

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