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Molecules 2018, 23(2), 275; https://doi.org/10.3390/molecules23020275

Lipase-Produced Hydroxytyrosyl Eicosapentaenoate is an Excellent Antioxidant for the Stabilization of Omega-3 Bulk Oils, Emulsions and Microcapsules

Centre for Chemistry and Biotechnology, Deakin University, Locked Bag 20000, Geelong, VIC 3220, Australia
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Received: 7 January 2018 / Revised: 26 January 2018 / Accepted: 27 January 2018 / Published: 29 January 2018
(This article belongs to the Special Issue Lipases and Lipases Modification)
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Abstract

In this study, several lipophilic hydroxytyrosyl esters were prepared enzymatically using immobilized lipase from Candida antarctica B. Oxidation tests showed that these conjugates are excellent antioxidants in lipid-based matrices, with hydroxytyrosyl eicosapentaenoate showing the highest antioxidant activity. Hydroxytyrosyl eicosapentaenoate effectively stabilized bulk fish oil, fish-oil-in-water emulsions and microencapsulated fish oil. The stabilizing effect of this antioxidant may either be because it orients itself with the omega-3 fatty acids in the oil, thereby protecting them against oxidation, or because this unstable fatty acid can preferentially oxidise, thus providing an additional mechanism of antioxidant protection. Hydroxytyrosyl eicosapentaenoate itself was stable for one year when stored at −20 °C. View Full-Text
Keywords: hydroxytyrosol; eicosapentaenoic acid; antioxidant; microencapsulation; lipase; Candida antarctica B; enzyme; conjugation hydroxytyrosol; eicosapentaenoic acid; antioxidant; microencapsulation; lipase; Candida antarctica B; enzyme; conjugation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Akanbi, T.O.; Barrow, C.J. Lipase-Produced Hydroxytyrosyl Eicosapentaenoate is an Excellent Antioxidant for the Stabilization of Omega-3 Bulk Oils, Emulsions and Microcapsules. Molecules 2018, 23, 275.

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