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Molecules 2018, 23(1), 84; https://doi.org/10.3390/molecules23010084

ROS Modulator Molecules with Therapeutic Potential in Cancers Treatments

Department “Development, Reproduction and Cancer”, Cochin Institute, INSERM U1016, University Paris Descartes, Paris 75014, France
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Received: 11 December 2017 / Revised: 28 December 2017 / Accepted: 30 December 2017 / Published: 31 December 2017
(This article belongs to the Special Issue Small Molecule Catalysts with Therapeutic Potential)
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Abstract

Reactive Oxygen Species (ROS) are chemically reactive chemical species containing oxygen. The redox status of a cell is function of the relative concentrations of oxidized and reduced forms of proteins, enzymes, ROS, molecules containing thiol and other factors. In the organism, the redox balance is based on the generation and elimination of ROS produced by endogenous and exogenous sources. All living organisms must maintain their redox equilibrium to survive and proliferate. Enzymatic and molecular pathways control ROS levels tightly but differentially depending on the type of cell. This review is an overview of various molecules that modulate ROS production/detoxification and have a synergistic action with the chemotherapies to kill cancer cells while preserving normal cells to avoid anticancer drugs side effects, allowing a better therapeutic index of the anticancer treatments. View Full-Text
Keywords: reactive oxygen species; cancer; redox status; antioxidant; SOD mimic reactive oxygen species; cancer; redox status; antioxidant; SOD mimic
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Nicco, C.; Batteux, F. ROS Modulator Molecules with Therapeutic Potential in Cancers Treatments. Molecules 2018, 23, 84.

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