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Molecules 2018, 23(1), 14; doi:10.3390/molecules23010014

The Effect of Resveratrol on Cell Viability in the Burkitt’s Lymphoma Cell Line Ramos

Instituto de Bioquímica y Microbiología, Facultad de Ciencias, Universidad Austral de Chile, Valdivia 5090000, Chile
Escuela de Tecnología Medica, Universidad Austral de Chile, Sede Puerto Montt 5480000, Chile
Instituto de Microbiología Clínica, Facultad de Medicina, Universidad Austral de Chile, Valdivia 5090000, Chile
Center for Interdisciplinary Studies on the Nervous System (CISNe), Universidad Austral de Chile, Valdivia 5090000, Chile
Author to whom correspondence should be addressed.
Received: 17 November 2017 / Revised: 12 December 2017 / Accepted: 13 December 2017 / Published: 21 December 2017
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Resveratrol is a polyphenolic natural compound produced by a variety of crops. Currently, resveratrol is considered a multi-target anti-cancer agent with pleiotropic activity, including the ability to prevent the proliferation of malignant cells by inhibiting angiogenesis and curtailing invasive and metastatic factors in many cancer models. However, the molecular mechanisms mediating resveratrol-specific effects on lymphoma cells remain unknown. To begin tackling this question, we treated the Burkitt’s lymphoma cell line Ramos with resveratrol and assessed cell survival and gene expression. Our results suggest that resveratrol shows a significant anti-proliferative and pro-apoptotic activity on Ramos cells, inducing the DNA damage response, DNA repairing, and modulating the expression of several genes that regulate the apoptotic process and their proliferative activity. View Full-Text
Keywords: resveratrol; cell viability; Ramos cells; DNA damage; DNA repair resveratrol; cell viability; Ramos cells; DNA damage; DNA repair

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Jara, P.; Spies, J.; Cárcamo, C.; Arancibia, Y.; Vargas, G.; Martin, C.; Salas, M.; Otth, C.; Zambrano, A. The Effect of Resveratrol on Cell Viability in the Burkitt’s Lymphoma Cell Line Ramos. Molecules 2018, 23, 14.

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