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Molecules 2018, 23(1), 13; doi:10.3390/molecules23010013

Antimicrobial Furoquinoline Alkaloids from Vepris lecomteana (Pierre) Cheek & T. Heller (Rutaceae)

Department of Chemistry, University of Douala, Faculty of Sciences, 24157 Douala, Cameroon
Organic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, 33501 Bielefeld, Germany
Department of Chemistry, University of Buea, Faculty of Sciences, 63 Buea, Cameroon
Authors to whom correspondence should be addressed.
Received: 25 November 2017 / Revised: 19 December 2017 / Accepted: 21 December 2017 / Published: 21 December 2017
(This article belongs to the Collection Bioactive Compounds)
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Three new prenylated furoquinoline alkaloids named lecomtequinoline A (1), B (2), and C (3), together with the known compounds anhydroevoxine (4), evoxine (5), dictamnine (6), N-methylflindersine (7), evoxanthine (8), hesperidin, lupeol, β-sitosterol, stigmasterol, β-sitosterol-3-O-β-d-glucopyranoside, stearic acid, and myristyl alcohol, were isolated by bioassay-guided fractionation of the methanolic extracts of leaves and stem of Vepris lecomteana. The structures of compounds were determined by spectroscopic methods (NMR, MS, UV, and IR) and by comparison with previously reported data. Crude extracts of leaves and stem displayed high antimicrobial activity, with Minimum Inhibitory Concentration (MIC) (values of 10.1–16.5 and 10.2–20.5 µg/mL, respectively, against Escherichia coli, Bacillus subtilis, Pseudomonas agarici, Micrococcus luteus, and Staphylococcus warneri, while compounds 16 showed values ranging from 11.1 to 18.7 µg/mL or were inactive, suggesting synergistic effect. The extracts may find application in crude drug preparations in Western Africa where Vepris lecomteana is endemic, subject to negative toxicity results in vivo. View Full-Text
Keywords: Vepris lecomteana; furoquinoline alkaloids; lecomte quinoline A–C Vepris lecomteana; furoquinoline alkaloids; lecomte quinoline A–C

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kouam, A.D.K.; Bissoue, A.N.; Tcho, A.T.; Happi, E.N.; Waffo, A.F.K.; Sewald, N.; Wansi, J.D. Antimicrobial Furoquinoline Alkaloids from Vepris lecomteana (Pierre) Cheek & T. Heller (Rutaceae). Molecules 2018, 23, 13.

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