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Molecules 2017, 22(12), 2226; https://doi.org/10.3390/molecules22122226

Bioactive Compounds from the Stems of Clausena lansium

1
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
2
Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
*
Author to whom correspondence should be addressed.
Received: 9 November 2017 / Revised: 9 December 2017 / Accepted: 11 December 2017 / Published: 14 December 2017
(This article belongs to the Collection Bioactive Compounds)
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Abstract

In view of the significant neuroprotective effect of Clausena lansium, we continued to separate the n-butanol and the water extracts from the stems of C. lansium in order to find the leading compounds with significant activity. Two new phenolic glycosides, Clausenolside A–B (12), one new pair of phenolic enantiomers (3a, 3b), and two new monoterpenoids, clausenapene A–B (45), together with twelve known analogues (617) were isolated from the stems of C. lansium. Compounds 117 were obtained from C. lansium for the first time. Compounds 3a, 3b, 4, 16, and 17 showed strong or moderate potential neuroprotective effects on inhibited PC12 cell injury induced by okadaic acid, and compound 9 exhibited strong potential hepatoprotective activities. Their structures were elucidated on the basis of spectroscopic analyses, including UV, IR, NMR experiments, and electronic circular dichroism (ECD) spectra. View Full-Text
Keywords: Clausena lansium; phenolic glycosides; terpenoids; neuroprotective activities; hepatoprotective activities Clausena lansium; phenolic glycosides; terpenoids; neuroprotective activities; hepatoprotective activities
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Liu, J.; Li, C.-J.; Du, Y.-Q.; Li, L.; Sun, H.; Chen, N.-H.; Zhang, D.-M. Bioactive Compounds from the Stems of Clausena lansium. Molecules 2017, 22, 2226.

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