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Molecules 2018, 23(1), 101; https://doi.org/10.3390/molecules23010101

Bioactivity-Guided Screening of Wound-Healing Active Constituents from American Cockroach (Periplaneta americana)

1
Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610065, China
2
Department of Pharmaceutical and Biological Engineering, School of Chemical Engineering, Sichuan University, Chengdu 610065, China
3
Sichuan Gooddoctor-Panxi Pharmaceutical Co., Ltd., Xichang 615000, China
*
Author to whom correspondence should be addressed.
Received: 12 December 2017 / Revised: 30 December 2017 / Accepted: 31 December 2017 / Published: 20 January 2018
(This article belongs to the Collection Bioactive Compounds)
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Abstract

Ethanol extract (EE) from Periplaneta americana (PA) is the main ingredient of Kangfuxin, which is a popular traditional chinese medicine (TCM) and has long been used for the clinical treatment of burns, wounds and ulcers. We compared the wound-healing activities of three extracts of PA using cutaneous wound-healing in mice as the bioactivity model. These three extracts were EE, total polysaccharide and total protein. We also tracked bioactive fractions in the EE by organic reagent extraction, column chromatography and HPLC. Seven compounds were successfully identified from the water elution fraction of the EE of PA using UPLC-MS. Among these compounds, four compounds (P2, P3, P4, P5(1)) were first reported in PA. Some of these compounds have been previously reported to have various pharmacological activities that could contribute to the high wound-healing activity of PA. View Full-Text
Keywords: Periplaneta americana; wound-healing activity; active constituents; bioactivity-guided screening Periplaneta americana; wound-healing activity; active constituents; bioactivity-guided screening
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Zhu, J.-J.; Yao, S.; Guo, X.; Yue, B.-S.; Ma, X.-Y.; Li, J. Bioactivity-Guided Screening of Wound-Healing Active Constituents from American Cockroach (Periplaneta americana). Molecules 2018, 23, 101.

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