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Molecules 2017, 22(8), 1283; doi:10.3390/molecules22081283

Three New Sesquiterpene Glycosides from the Rhizomes of Trillium tschonoskii

1
School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China
2
Beijing Institute of Radiation Medicine, No. 27, Taiping Road, Beijing 100850, China
3
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Beijing 100193, China
*
Author to whom correspondence should be addressed.
Received: 24 June 2017 / Revised: 1 August 2017 / Accepted: 1 August 2017 / Published: 2 August 2017
(This article belongs to the Special Issue Diversity of Terpenoids)
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Abstract

Three new sesquiterpene glycosides, possessing a rare aglycone with a sulfonyl between C-1 and C-15 positions, named 3-(3′E-7′R,8′-dihydroxy-4′,8′-dimethyl-3′-nonenyl)-2,5-dihydro-1,1-dioxo-thiophen 7′-O-β-d-glucopyranosyl-(1→4)-O-β-d-glucopyranosyl-(1→4)-O-β-d-glucopyranoside (1), 3-(3′E-7′R,8′-dihydroxy-4′,8′-dimethyl-3′-nonenyl)-2,5-dihydro-1,1-dioxo-thiophen 7′-O-β-d-glucopyranosyl-(1→4)-O-β-d-glucopyranoside (2), and 3-(3′E-7′R,8′-dihydroxy-4′,8′-dimethyl-3′-nonenyl)-2,5-dihydro-1,1-dioxo-thiophen 7′-O-β-d-glucopyranosyl-6′-O-acetyl-(1→4)-O-β-d-glucopyranosyl-(1→4)-O-β-d-glucopyranoside (3), respectively, were isolated from the rhizomes of Trillium tschonoskii. Their structures were established on the basis of spectroscopic data, including HR-ESI-MS, IR, 1D and 2D NMR. The cytotoxic properties of the three compounds were investigated using human hepatic L02 cells. View Full-Text
Keywords: Trillium tschonoskii; sesquiterpene glycosides; separation Trillium tschonoskii; sesquiterpene glycosides; separation
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Yang, J.; Yang, Y.-J.; Sun, X.-G.; Zhang, J.; Zhao, Y.; Wang, B.; Ding, Q.-Z.; Guo, B.-L.; Ma, B.-P. Three New Sesquiterpene Glycosides from the Rhizomes of Trillium tschonoskii. Molecules 2017, 22, 1283.

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