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Molecules 2017, 22(8), 1263; doi:10.3390/molecules22081263

Recent Developments in the Medicinal Applications of Silver-NHC Complexes and Imidazolium Salts

1
Department of Chemistry, 401 College Ave., Ashland University, Ashland, OH 44805, USA
2
Department of Chemistry, University of Akron, Akron, OH 44325, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Sylvain Roland
Received: 1 July 2017 / Revised: 21 July 2017 / Accepted: 22 July 2017 / Published: 27 July 2017

Abstract

Because of their great structural diversity and multitude of chemical properties, N-heterocyclic carbenes (NHCs) have been utilized in a variety of capacities. Most recently, NHCs have been utilized as carrier molecules for many transition metals in medicinal chemistry. Specifically, Ag(I)-NHCs have been investigated as potent antibacterial agents and chemotherapeutics and have shown great efficacy in both in vitro and in vivo studies. Ag(I)-NHC compounds have been shown to be effective against a wide range of both Gram-positive and Gram-negative bacterial strains. Many compounds have also shown great efficacy as antitumor agents demonstrating comparable or better antitumor activity than standard chemotherapeutics such as cisplatin and 5-fluorouracil. While these compounds have shown great promise, clinical use has remained an unattained goal. Current research has been focused upon synthesis of novel Ag(I)-NHC compounds and further investigations of their antibacterial and antitumor activity. This review will focus on recent advances of Ag(I)-NHCs in medicinal applications. View Full-Text
Keywords: silver; NHC; imidazolium salt; antibacterial; antitumor; chemotherapeutic silver; NHC; imidazolium salt; antibacterial; antitumor; chemotherapeutic
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Johnson, N.A.; Southerland, M.R.; Youngs, W.J. Recent Developments in the Medicinal Applications of Silver-NHC Complexes and Imidazolium Salts. Molecules 2017, 22, 1263.

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