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Molecules 2017, 22(7), 1168; doi:10.3390/molecules22071168

Isolation and Characterization of Aphidicolin Derivatives from Tolypocladium inflatum

1
Jiangsu Key Laboratory for Biofunctional Molecules, College of Life Science and Chemistry,Jiangsu Second Normal University, Nanjing 210003, China
2
School of Biomedicine, Beijing City University, Beijing 100083, China
3
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 14 June 2017 / Revised: 8 July 2017 / Accepted: 8 July 2017 / Published: 12 July 2017
(This article belongs to the Collection Bioactive Compounds)
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Abstract

Inflatin G (1), a new aphidicolin analogue, together with seven known compounds inflatin A (2), inflatin B (3), aphidicolin (4), aphidicolin-17-monoacetate (5), gulypyrone A (6), pyridoxatin rotamers A (7) and B (8), were isolated from the ascomycete fungus Tolypocladium inflatum. Their structures were determined through NMR analyses and the circular dichroism data of the in situ formed [Rh2(OCOCF3)4] complexes. Compounds 1, 4, 5, 7, and 8 showed modest cytotoxicity against four human cancer cell lines A549, CNE1-MP1, A375, and MCF-7. View Full-Text
Keywords: Tolypocladium inflatum; structure elucidation; biological activities Tolypocladium inflatum; structure elucidation; biological activities
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Lin, J.; Niu, S.; Ding, Z.; Wang, R.; Dai, Q.; Wei, W.; Luo, R.; Liu, L. Isolation and Characterization of Aphidicolin Derivatives from Tolypocladium inflatum. Molecules 2017, 22, 1168.

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