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Molecules 2017, 22(6), 988; doi:10.3390/molecules22060988

Serum Uromodulin Levels in Prediction of Acute Kidney Injury in the Early Phase of Acute Pancreatitis

1
Department of Diagnostics, Chair of Clinical Biochemistry, Jagiellonian University Medical College, 31-501 Kraków, Poland
2
St. Queen Jadwiga Clinical District Hospital No2 in Rzeszow, 35-301 Rzeszów, Poland
3
Department of Diagnostics, University Hospital, 31-501 Kraków, Poland
4
Department of Medical Diagnostics, Jagiellonian University Medical College, 30-688 Kraków, Poland
5
Department of Anatomy, Jagiellonian University Medical College, 31-034 Kraków, Poland
6
Surgery Department, The District Hospital, 34-200 Sucha Beskidzka, Poland
7
Department of Pathophysiology, Faculty of Medicine, Jagiellonian University Medical College, 31-121 Kraków, Poland
8
Department of Physiology, Jagiellonian University Medical College, 31-531 Kraków, Poland
9
Department of Experimental and Clinical Surgery, Jagiellonian University Medical College, 31-126 Kraków, Poland
10
2nd Department of Surgery, Faculty of Medicine, Jagiellonian University Medical College, 31-501 Kraków, Poland
11
Department of Cardiovascular Surgery and Transplantology, Faculty of Medicine, Jagiellonian University Medical College, 31-202 Kraków, Poland
12
Chair and Department of Nephrology, Jagiellonian University Medical College, 31-501 Kraków, Poland
*
Author to whom correspondence should be addressed.
Received: 10 May 2017 / Revised: 9 June 2017 / Accepted: 12 June 2017 / Published: 14 June 2017
(This article belongs to the Section Bioorganic Chemistry)
View Full-Text   |   Download PDF [851 KB, uploaded 14 June 2017]   |  

Abstract

In health, uromodulin is the main protein of urine. Serum uromodulin concentrations (sUMOD) have been shown to correlate with kidney function. Acute kidney injury (AKI) is among the main complications of severe acute pancreatitis (AP). No reports exist on sUMOD in patients with AP, including the diagnostic usefulness for early prediction of AP severity. We measured sUMOD during first 72 h of AP. Sixty-six adult patients with AP were recruited at the surgical ward of the District Hospital in Sucha Beskidzka, Poland. AP was diagnosed according to the Revised Atlanta Classification. Blood samples were collected at 24, 48 and 72 h of AP, and sUMOD concentrations were measured with enzyme-linked immunosorbent test. sUMOD decreased non-significantly during the study. Patients with severe AP had non-significantly lower sUMOD concentrations than those with mild disease. Significant positive correlation was observed between sUMOD and estimated glomerular filtration rate on each day of the study and negative correlations were shown between sUMOD and age, serum creatinine, cystatin C and urea. Patients with AKI tended to have lower sUMOD. Although sUMOD correlated significantly with kidney function in the early phase of AP, measuring sUMOD did not allow to reliably predict AP severity or development of AKI. View Full-Text
Keywords: glycoproteins; uromodulin; acute pancreatitis; acute kidney injury glycoproteins; uromodulin; acute pancreatitis; acute kidney injury
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Kuśnierz-Cabala, B.; Gala-Błądzińska, A.; Mazur-Laskowska, M.; Dumnicka, P.; Sporek, M.; Matuszyk, A.; Gil, K.; Ceranowicz, P.; Walocha, J.; Kucharz, J.; Pędziwiatr, M.; Bartuś, K.; Trąbka, R.; Kuźniewski, M. Serum Uromodulin Levels in Prediction of Acute Kidney Injury in the Early Phase of Acute Pancreatitis. Molecules 2017, 22, 988.

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