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Molecules 2017, 22(6), 991; doi:10.3390/molecules22060991

Five Unprecedented Secondary Metabolites from the Spider Parasitic Fungus Akanthomyces novoguineensis

1
Department of Microbial Drugs, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany
2
Department of Chemistry, Faculty of Science, Aswan University, Aswan 81528, Egypt
3
Department of Microbiology, Faculty of Science, Prince of Songkla University, Songkhla 90112, Thailand
4
Natural Products Research Center of Excellence and Department of Microbiology, Prince of Songkla University, Songkhla 90112, Thailand
5
National Centre for Genetic Engineering and Biotechnology (BIOTEC), Pathumthani 12120, Thailand
6
Department of Chemistry, Faculty of Science, Prince of Songkla University, Songkhla 90112, Thailand
7
Center of Excellence for Innovation in Chemistry, Prince of Songkla University, Songkhla 90112, Thailand
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 4 May 2017 / Revised: 31 May 2017 / Accepted: 1 June 2017 / Published: 14 June 2017
View Full-Text   |   Download PDF [1105 KB, uploaded 16 June 2017]   |  

Abstract

Five new compounds including the glycosylated β-naphthol (1, akanthol), a glycosylated pyrazine (2, akanthozine), and three amide derivatives including a hydroxamic acid derivative (35) were isolated from the spider-associated fungus Akanthomyces novoguineensis (Cordycipitaceae, Ascomycota). Their structures were elucidated by using high resolution mass spectrometry (HRMS) and NMR spectroscopy. In this study, the antimicrobial, cytotoxic, anti-biofilm, and nematicidal activities of the new compounds were evaluated. The distribution pattern of secondary metabolites in the species was also revealed in which more isolates of A. novoguineensis were encountered and their secondary metabolite profiles were examined using analytical HPLC with diode array and mass spectrometric detection (HPLC-DAD/MS). Remarkably, all isolated compounds are specifically produced by A. novoguineensis. View Full-Text
Keywords: akanthol; akanthozine; Akanthomyces novoguineensis; hydroxamic acid; chemotaxonomy akanthol; akanthozine; Akanthomyces novoguineensis; hydroxamic acid; chemotaxonomy
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Helaly, S.E.; Kuephadungphan, W.; Phongpaichit, S.; Luangsa-ard, J.J.; Rukachaisirikul, V.; Stadler, M. Five Unprecedented Secondary Metabolites from the Spider Parasitic Fungus Akanthomyces novoguineensis. Molecules 2017, 22, 991.

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