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Molecules 2017, 22(6), 977; doi:10.3390/molecules22060977

Fluoroalkyl Amino Reagents (FARs): A General Approach towards the Synthesis of Heterocyclic Compounds Bearing Emergent Fluorinated Substituents

1
University of Strasbourg, CNRS, LCM UMR 7509, 67000 Strasbourg, France
2
Bayer S.A.S., 14 Impasse Pierre Baizet, BP 99163, 69263 Lyon CEDEX 09, France
3
Bayer AG, Alfred-Nobel-Strasse 50, 40789 Monheim, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Thierry Billard
Received: 20 May 2017 / Revised: 6 June 2017 / Accepted: 7 June 2017 / Published: 12 June 2017

Abstract

Fluorinated heterocycles are important building blocks in pharmaceutical, agrochemical and material sciences. Therefore, organofluorine chemistry has witnessed high interest in the development of efficient methods for the introduction of emergent fluorinated substituents (EFS) onto heterocycles. In this context, fluoroalkyl amino reagents (FARs)—a class of chemicals that was slightly forgotten over the last decades—has emerged again recently and proved to be a powerful tool for the introduction of various fluorinated groups onto (hetero)aromatic derivatives. View Full-Text
Keywords: fluorine; FAR; heterocycles; fluoroalkyl; difluoromethyl; emergent fluorinated substituents fluorine; FAR; heterocycles; fluoroalkyl; difluoromethyl; emergent fluorinated substituents
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MDPI and ACS Style

Commare, B.; Schmitt, E.; Aribi, F.; Panossian, A.; Vors, J.-P.; Pazenok, S.; Leroux, F.R. Fluoroalkyl Amino Reagents (FARs): A General Approach towards the Synthesis of Heterocyclic Compounds Bearing Emergent Fluorinated Substituents. Molecules 2017, 22, 977.

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