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Molecules 2017, 22(6), 907; doi:10.3390/molecules22060907

Five New Limonoids from Peels of Satsuma Orange (Citrus reticulata)

Faculty of Pharmaceutical Sciences, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1142, Japan
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 21 April 2017 / Accepted: 26 May 2017 / Published: 31 May 2017
(This article belongs to the Section Natural Products)
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Five new: 21,23-dihydro-21-hydroxy-23-oxonomilin (1), 21,23-dihydro-23-methoxy-21-oxonomilin (2), 21,23-dihydro-21-hydroxy-23-oxonomilinic acid methyl ester (3), 21,23-dihydro-23-methoxy-21-oxolimonin (4), and 21,23-dihydro-21-oxolimonin (5), and seven known limonoids were isolated from peels of satsuma orange (Citrus reticulata). The isolated compounds were evaluated for their inhibitory effects on macrophage activation by an inhibitory assay of nitric oxide (NO) production. Among them, compound (2) exhibited NO inhibitory activity without cytotoxicity. View Full-Text
Keywords: limonoid; Rutaceae; satsuma orange; Citrus reticulata; inhibitory activity on nitric oxide production limonoid; Rutaceae; satsuma orange; Citrus reticulata; inhibitory activity on nitric oxide production

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Kikuchi, T.; Ueno, Y.; Hamada, Y.; Furukawa, C.; Fujimoto, T.; Yamada, T.; Tanaka, R. Five New Limonoids from Peels of Satsuma Orange (Citrus reticulata). Molecules 2017, 22, 907.

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