Total Synthesis and Pharmacological Investigation of Cordyheptapeptide A
AbstractThe present investigation reports the synthesis of a phenylalanine-rich N-methylated cyclopeptide, cordyheptapeptide A (8), previously isolated from the insect pathogenic fungus Cordyceps sp. BCC 1788, accomplished through the coupling of N-methylated tetrapeptide and tripeptide fragments followed by cyclization of the linear heptapeptide unit. Structure elucidation of the newly synthesized cyclopolypeptide was performed by means of FT-IR, 1H-NMR, 13C-NMR, and fast atom bombardment mass spectrometry (FABMS), and screened for its antibacterial, antidermatophytic, and cytotoxic potential. According to the antimicrobial activity results, the newly synthesized N-Methylated cyclopeptide exhibited potent antibacterial activity against Gram-negative bacteria Pseudomonas aeruginosa and Klebsiella pneumoniae and antifungal activity against dermatophytes Trichophyton mentagrophytes and Microsporum audouinii at a concentration of 6 μg/mL, in comparison to the reference drugs, gatifloxacin and griseofulvin. In addition, cyclopolypeptide 8 displayed suitable levels of cytotoxicity against Dalton’s lymphoma ascites (DLA) and Ehrlich’s ascites carcinoma (EAC) cell lines. View Full-Text
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Kumar, S.; Dahiya, R.; Khokra, S.L.; Mourya, R.; Chennupati, S.V.; Maharaj, S. Total Synthesis and Pharmacological Investigation of Cordyheptapeptide A. Molecules 2017, 22, 682.
Kumar S, Dahiya R, Khokra SL, Mourya R, Chennupati SV, Maharaj S. Total Synthesis and Pharmacological Investigation of Cordyheptapeptide A. Molecules. 2017; 22(6):682.Chicago/Turabian Style
Kumar, Suresh; Dahiya, Rajiv; Khokra, Sukhbir L.; Mourya, Rita; Chennupati, Suresh V.; Maharaj, Sandeep. 2017. "Total Synthesis and Pharmacological Investigation of Cordyheptapeptide A." Molecules 22, no. 6: 682.
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