From Farm to Pharma: An Overview of Industrial Heparin Manufacturing Methods
AbstractThe purification of heparin from offal is an old industrial process for which commercial recipes date back to 1922. Although chemical, chemoenzymatic, and biotechnological alternatives for this production method have been published in the academic literature, animal-tissue is still the sole source for commercial heparin production in industry. Heparin purification methods are closely guarded industrial secrets which are not available to the general (scientific) public. However by reviewing the academic and patent literature, we aim to provide a comprehensive overview of the general methods used in industry for the extraction of heparin from animal tissue. View Full-Text
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van der Meer, J.-Y.; Kellenbach, E.; van den Bos, L.J. From Farm to Pharma: An Overview of Industrial Heparin Manufacturing Methods. Molecules 2017, 22, 1025.
van der Meer J-Y, Kellenbach E, van den Bos LJ. From Farm to Pharma: An Overview of Industrial Heparin Manufacturing Methods. Molecules. 2017; 22(6):1025.Chicago/Turabian Style
van der Meer, Jan-Ytzen; Kellenbach, Edwin; van den Bos, Leendert J. 2017. "From Farm to Pharma: An Overview of Industrial Heparin Manufacturing Methods." Molecules 22, no. 6: 1025.
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