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Molecules 2017, 22(6), 1025; doi:10.3390/molecules22061025

From Farm to Pharma: An Overview of Industrial Heparin Manufacturing Methods

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Academic Editors: Giangiacomo Torri and Jawed Fareed
Received: 19 May 2017 / Accepted: 18 June 2017 / Published: 21 June 2017
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Abstract

The purification of heparin from offal is an old industrial process for which commercial recipes date back to 1922. Although chemical, chemoenzymatic, and biotechnological alternatives for this production method have been published in the academic literature, animal-tissue is still the sole source for commercial heparin production in industry. Heparin purification methods are closely guarded industrial secrets which are not available to the general (scientific) public. However by reviewing the academic and patent literature, we aim to provide a comprehensive overview of the general methods used in industry for the extraction of heparin from animal tissue. View Full-Text
Keywords: heparin; heparin process; manufacturing methods; industrial heparin; heparin process; manufacturing methods; industrial
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van der Meer, J.-Y.; Kellenbach, E.; van den Bos, L.J. From Farm to Pharma: An Overview of Industrial Heparin Manufacturing Methods. Molecules 2017, 22, 1025.

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