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Molecules 2017, 22(6), 1026; doi:10.3390/molecules22061026

Screening and Identification of the Metabolites in Rat Plasma and Urine after Oral Administration of Areca catechu L. Nut Extract by Ultra-High-Pressure Liquid Chromatography Coupled with Linear Ion Trap–Orbitrap Tandem Mass Spectrometry

1
School of Chinese Materia Medica, Beijing University of Chinese Medicine, No. 6, Zhonghuan South Road, Wangjing, Chaoyang District, Beijing 100102, China
2
Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, No. 11, North Third Ring Road, Chaoyang District, Beijing 100029, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 6 June 2017 / Revised: 18 June 2017 / Accepted: 19 June 2017 / Published: 21 June 2017
(This article belongs to the Section Metabolites)
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Abstract

Areca catechu L. nut, a well-known toxic traditional herbal medicine, has been widely used to treat various diseases in China and many other Asian countries for centuries. However, to date the in vivo absorption and metabolism of its multiple bioactive or toxic components still remain unclear. In this study, liquid chromatography coupled with tandem mass spectrometry was used to analyze the major components and their metabolites in rat plasma and urine after oral administration of Areca catechu L. nut extract (ACNE). A total of 12 compounds, including 6 alkaloids, 3 tannins and 3 amino acids, were confirmed or tentatively identified from ACNE. In vivo, 40 constituents, including 8 prototypes and 32 metabolites were identified in rat plasma and urine samples. In summary, this study showed an insight into the metabolism of ACNE in vivo, which may provide helpful chemical information for better understanding of the toxicological and pharmacological profiles of ACNE. View Full-Text
Keywords: Areca catechu L.; major compounds; metabolites; UHPLC-LTQ-Orbitrap Areca catechu L.; major compounds; metabolites; UHPLC-LTQ-Orbitrap
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Li, L.; Luo, Z.; Liu, Y.; Wang, H.; Liu, A.; Yu, G.; Li, M.; Yang, R.; Chen, X.; Zhu, J.; Zhao, B. Screening and Identification of the Metabolites in Rat Plasma and Urine after Oral Administration of Areca catechu L. Nut Extract by Ultra-High-Pressure Liquid Chromatography Coupled with Linear Ion Trap–Orbitrap Tandem Mass Spectrometry. Molecules 2017, 22, 1026.

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