Next Article in Journal
Herb-Drug Interaction between the Traditional Hepatoprotective Formulation and Sorafenib on Hepatotoxicity, Histopathology and Pharmacokinetics in Rats
Next Article in Special Issue
Structural Characterization of the Low-Molecular-Weight Heparin Dalteparin by Combining Different Analytical Strategies
Previous Article in Journal
Use of Chitosan-PVA Hydrogels with Copper Nanoparticles to Improve the Growth of Grafted Watermelon
Previous Article in Special Issue
From Farm to Pharma: An Overview of Industrial Heparin Manufacturing Methods
Article Menu
Issue 7 (July) cover image

Export Article

Open AccessFeature PaperArticle
Molecules 2017, 22(7), 1030; doi:10.3390/molecules22071030

Albumin and Hyaluronic Acid-Coated Superparamagnetic Iron Oxide Nanoparticles Loaded with Paclitaxel for Biomedical Applications

1
Department of Chemistry, Materials and Chemical Engineering “G. Natta”, Politecnico di Milano, 20131 Milano, Italy
2
Biotechnology and Food Engineering Department, Technion-Israel Institute of Technology, Haifa 3200000, Israel
3
Department of Materials Science, University of Milan Bicocca, 20125 Milano, Italy
4
Istituto scientifico di chimica e biochimica “G. Ronzoni”, 20133 Milano, Italy
5
Biology Department, Technion-Israel Institute of Technology, Haifa 3200000, Israel
*
Authors to whom correspondence should be addressed.
Academic Editors: Jawed Fareed, Giangiacomo Torri and Diego Muñoz-Torrero
Received: 22 May 2017 / Accepted: 16 June 2017 / Published: 22 June 2017
View Full-Text   |   Download PDF [22343 KB, uploaded 29 June 2017]   |  

Abstract

Super paramagnetic iron oxide nanoparticles (SPION) were augmented by both hyaluronic acid (HA) and bovine serum albumin (BSA), each covalently conjugated to dopamine (DA) enabling their anchoring to the SPION. HA and BSA were found to simultaneously serve as stabilizing polymers of Fe3O4·DA-BSA/HA in water. Fe3O4·DA-BSA/HA efficiently entrapped and released the hydrophobic cytotoxic drug paclitaxel (PTX). The relative amount of HA and BSA modulates not only the total solubility but also the paramagnetic relaxation properties of the preparation. The entrapping of PTX did not influence the paramagnetic relaxation properties of Fe3O4·DA-BSA. Thus, by tuning the surface structure and loading, we can tune the theranostic properties of the system. View Full-Text
Keywords: super paramagnetic iron oxide nanoparticles (SPION); hyaluronic acid (HA); bovine serum albumin (BSA); Fe3O4·DA-BSA/HA; paclitaxel (PTX); magnetic resonance imaging (MRI) super paramagnetic iron oxide nanoparticles (SPION); hyaluronic acid (HA); bovine serum albumin (BSA); Fe3O4·DA-BSA/HA; paclitaxel (PTX); magnetic resonance imaging (MRI)
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Vismara, E.; Bongio, C.; Coletti, A.; Edelman, R.; Serafini, A.; Mauri, M.; Simonutti, R.; Bertini, S.; Urso, E.; Assaraf, Y.G.; Livney, Y.D. Albumin and Hyaluronic Acid-Coated Superparamagnetic Iron Oxide Nanoparticles Loaded with Paclitaxel for Biomedical Applications. Molecules 2017, 22, 1030.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top