Next Article in Journal
Impact of a Microbial Cocktail Used as a Starter Culture on Cocoa Fermentation and Chocolate Flavor
Previous Article in Journal
Phytochemical Profiles and Antimicrobial Activities of Allium cepa Red cv. and A. sativum Subjected to Different Drying Methods: A Comparative MS-Based Metabolomics
Previous Article in Special Issue
The Mechanism of Room-Temperature Ionic-Liquid-Based Electrochemical CO2 Reduction: A Review
Article Menu
Issue 5 (May) cover image

Export Article

Open AccessArticle
Molecules 2017, 22(5), 762; doi:10.3390/molecules22050762

Ionic Liquid as an Efficient Medium for the Synthesis of Quinoline Derivatives via α-Chymotrypsin-Catalyzed Friedländer Condensation

1
Jiangxi 2011 Joint Center for the Innovative Mass Spectrometry and Instrumentation, East China University of Technology, Nanchang 330013, China
2
School of Chemistry, Biology and Material Science, East China University of Technology, Nanchang 330013, China
*
Author to whom correspondence should be addressed.
Academic Editor: Hua Zhao
Received: 30 March 2017 / Revised: 26 April 2017 / Accepted: 4 May 2017 / Published: 8 May 2017
View Full-Text   |   Download PDF [8800 KB, uploaded 8 May 2017]   |  

Abstract

An efficient, convenient, and eco-friendly biocatalytic approach was developed for the synthesis of quinoline derivatives via the α-chymotrypsin-catalyzed Friedländer reaction. Interestingly, α-chymotrypsin exhibited higher catalytic activity in an ionic liquid (IL) aqueous solution as compared to that observed in our previous relevant study, which was conducted using an organic solvent, and a series of substrates gave similar excellent yields at lower reaction temperature and under reduced enzyme-loading conditions. View Full-Text
Keywords: Friedländer reaction; quinolines; α-chymotrypsin; ionic liquid; biocatalysis; promiscuity Friedländer reaction; quinolines; α-chymotrypsin; ionic liquid; biocatalysis; promiscuity
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Le, Z.-G.; Liang, M.; Chen, Z.-S.; Zhang, S.-H.; Xie, Z.-B. Ionic Liquid as an Efficient Medium for the Synthesis of Quinoline Derivatives via α-Chymotrypsin-Catalyzed Friedländer Condensation. Molecules 2017, 22, 762.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top