Synthesis of Aminoglycoside-2′-O-Methyl Oligoribonucleotide Fusions
AbstractPhosphoramidite building blocks of ribostamycin (3 and 4), that may be incorporated at any position of the oligonucleotide sequence, were synthesized. The building blocks, together with a previously described neomycin-modified solid support, were applied for the preparation of aminoglycoside-2′-O-methyl oligoribonucleotide fusions. The fusions were used to clamp a single strand DNA sequence (a purine-rich strand of c-Myc promoter 1) to form triple helical 2′-O-methyl RNA/DNA-hybrid constructs. The potential of the aminoglycoside moieties to stabilize the triple helical constructs were studied by UV-melting profile analysis. View Full-Text
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Granqvist, L.; Kraszewski, A.; Tähtinen, V.; Virta, P. Synthesis of Aminoglycoside-2′-O-Methyl Oligoribonucleotide Fusions. Molecules 2017, 22, 760.
Granqvist L, Kraszewski A, Tähtinen V, Virta P. Synthesis of Aminoglycoside-2′-O-Methyl Oligoribonucleotide Fusions. Molecules. 2017; 22(5):760.Chicago/Turabian Style
Granqvist, Lotta; Kraszewski, Andrzej; Tähtinen, Ville; Virta, Pasi. 2017. "Synthesis of Aminoglycoside-2′-O-Methyl Oligoribonucleotide Fusions." Molecules 22, no. 5: 760.
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