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Open AccessCommunication
Molecules 2017, 22(5), 765; doi:10.3390/molecules22050765

Two New Metabolites from the Endophytic Fungus Alternaria sp. A744 Derived from Morinda officinalis

1
State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, China
2
School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411100, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 1 April 2017 / Revised: 3 May 2017 / Accepted: 4 May 2017 / Published: 8 May 2017
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [941 KB, uploaded 8 May 2017]   |  

Abstract

Two new compounds isobenzofuranone A (1) and indandione B (2), together with eleven known compounds (313) were isolated from liquid cultures of an endophytic fungus Alternaria sp., which was obtained from the medicinal plant Morinda officinalis. Among them, the indandione (2) showed a rarely occurring indanone skeleton in natural products. Their structures were elucidated mainly on the basis of extensive spectroscopic data analysis. All of the compounds were evaluated with cytotoxic and α-glucosidase inhibitory activity assays. Compounds 11 and 12 showed significant inhibitory activities against four tumor cell lines; MCF-7, HepG-2, NCI-H460 and SF-268, with IC50 values in the range of 1.91–9.67 μM, and compounds 4, 5, 9, 10, 12 and 13 showed excellent inhibitory activities against α-glucosidase with IC50 values in the range of 12.05–166.13 μM. View Full-Text
Keywords: Alternaria sp.; endophytic fungus; Morinda officinalis; cytotoxicity; α-glucosidase inhibitory Alternaria sp.; endophytic fungus; Morinda officinalis; cytotoxicity; α-glucosidase inhibitory
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MDPI and ACS Style

Wang, Y.; Liu, H.-X.; Chen, Y.-C.; Sun, Z.-H.; Li, H.-H.; Li, S.-N.; Yan, M.-L.; Zhang, W.-M. Two New Metabolites from the Endophytic Fungus Alternaria sp. A744 Derived from Morinda officinalis. Molecules 2017, 22, 765.

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