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Molecules 2017, 22(5), 717; doi:10.3390/molecules22050717

Chemical Comparison of Two Drying Methods of Mountain Cultivated Ginseng by UPLC-QTOF-MS/MS and Multivariate Statistical Analysis

1
School of Chinese Materia Medica, Beijing University of Chinese Medicine, No. 6 Wangjing zhonghuannan Road, Beijing 100102, China
2
Beijing Key Laboratory for Quality Evaluation of Chinese Materia Medica, Beijing University of Chinese Medicine, No. 11 North Third Ring Road, Beijing 100029, China
*
Author to whom correspondence should be addressed.
Academic Editor: Anusha Chaparala
Received: 14 April 2017 / Revised: 26 April 2017 / Accepted: 27 April 2017 / Published: 30 April 2017
(This article belongs to the Special Issue Current Trends in Ginseng Research)
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Abstract

In traditional Chinese medicine practice, drying method is an essential factor to influence the components of Chinese medicinal herbs. In this study, an ultra-performance liquid chromatography quadrupole time-of-flight tandem mass spectrometry (UPLC-QTOF-MS/MS)-based approach was used to compare the content of chemical compounds of mountain cultivated ginseng that had been natural air dried (LX-P) and vacuum freeze-dried (LX-L). Multivariate statistical analysis such as principal component analysis (PCA) and supervised orthogonal partial least squared discrimination analysis (OPLS-DA) were used to select the influential components of different samples. There were 41 ginsenosides unambiguously identified and tentatively assigned in both LX-L and LX-P. The results showed that the characteristic components in LX-P were ginsenoside Rb1, ginsenoside Rc, ginsenoside Rg6, dendrolasin, and ginsenoside Rb2. The characteristic components in LX-L were malonyl-ginsenoside Re, malonyl-ginsenoside Rb1, malonyl-ginsenoside Rc, malonyl-ginsenoside Rb1 isomer, malonyl-ginsenoside Rb2, malonyl-ginsenoside Rb3, malonyl-ginsenoside Rd isomer, gypenoside XVII, and notoginsenoside Fe. This is the first time that the differences between LX-L and LX-P have been observed systematically at the chemistry level. It was indicated that vacuum freeze-drying method can improve the content of malonyl-ginsensides in mountain cultivated ginseng. View Full-Text
Keywords: mountain cultivated ginseng (MCG); UPLC-QTOF-MS/MS; OPLS-DA; PCA; vacuum freeze-drying mountain cultivated ginseng (MCG); UPLC-QTOF-MS/MS; OPLS-DA; PCA; vacuum freeze-drying
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Xu, X.-F.; Xu, S.-Y.; Zhang, Y.; Zhang, H.; Liu, M.-N.; Liu, H.; Gao, Y.; Xue, X.; Xiong, H.; Lin, R.-C.; Li, X.-R. Chemical Comparison of Two Drying Methods of Mountain Cultivated Ginseng by UPLC-QTOF-MS/MS and Multivariate Statistical Analysis. Molecules 2017, 22, 717.

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