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Molecules 2017, 22(4), 611; doi:10.3390/molecules22040611

Structural Analysis and Immuno-Stimulating Activity of an Acidic Polysaccharide from the Stems of Dendrobium nobile Lindl.

School of Food Science and Engineering, Hefei University of Technology, Hefei 230009, China
Authors to whom correspondence should be addressed.
Academic Editors: Quan-Bin Han, Sunan Wang and Shaoping Nie
Received: 16 March 2017 / Revised: 5 April 2017 / Accepted: 5 April 2017 / Published: 10 April 2017
(This article belongs to the Special Issue Natural Polysaccharides)
View Full-Text   |   Download PDF [1693 KB, uploaded 11 April 2017]   |  


Dendrobium nobile Lindl., an epiphytic herb distributed in the Southeast Asia, is used as a tonic and antipyretic herbal medicine in China. In this study, a water-soluble acidic heteropolysaccharide, DNP-W4, containing mannose, glucose, galactose, xylose, rhamnose, and galacturonic acid, in the molar ratios of 1.0:4.9:2.5:0.5:1.0:0.9, was obtained from the stems of Dendrobium nobile Lindl. Using methylation analysis, partial acid hydrolysis, pectolyase treatment, NMR, and ESI-MS, the structure of DNP-W4 was elucidated. The obtained data indicated that DNP-W4 was a complex heteropolysaccharide and possessed a backbone composed of (1→4)-linked β-d-Glcp, (1→6)-linked β-d-Glcp, and (1→6)-linked β-d-Galp, with substitutes at O-4/6 of Glcp residues and O-3 of Galp. The branches of DNP-W4 were composed of terminal Manp, (1→6)-linked β-d-Manp, (1→3)-linked β-d-Glcp, β-d-Glcp, β-d-Galp, (1→4)-linked α-d-GalAp, (1→2)-linked α-L-Rhap, and Xylp. DNP-W4 had little immunological activities, but its derivatives had immuno-stimulating activities to some extent. View Full-Text
Keywords: Dendrobium nobile Lindl.; polysaccharide; acidic polysaccharide; immunological activities Dendrobium nobile Lindl.; polysaccharide; acidic polysaccharide; immunological activities

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Wang, J.-H.; Zuo, S.-R.; Luo, J.-P. Structural Analysis and Immuno-Stimulating Activity of an Acidic Polysaccharide from the Stems of Dendrobium nobile Lindl.. Molecules 2017, 22, 611.

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