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Molecules 2017, 22(3), 442; doi:10.3390/molecules22030442

A Strategy for Simultaneous Isolation of Less Polar Ginsenosides, Including a Pair of New 20-Methoxyl Isomers, from Flower Buds of Panax ginseng

1
College of Medical, Dalian University, Dalian 116622, China
2
College of Environmental and Chemical Engineering, Dalian University, Dalian 116622, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Thomas J. Schmidt
Received: 25 January 2017 / Accepted: 9 March 2017 / Published: 10 March 2017
(This article belongs to the Special Issue Current Trends in Ginseng Research)
View Full-Text   |   Download PDF [1609 KB, uploaded 14 March 2017]   |  

Abstract

The present study was designed to simultaneously isolate the less polar ginsenosides from the flower buds of Panax ginseng (FBPG). Five ginsenosides, including a pair of new 20-methoxyl isomers, were extracted from FBPG and purified through a five-step integrated strategy, by combining ultrasonic extraction, Diaion Hp-20 macroporous resin column enrichment, solid phase extraction (SPE), reversed-phase high-performance liquid chromatography (RP-HPLC) analysis and preparation, and nuclear magnetic resonance (NMR) analysis. The quantification of the five ginsenosides was also discussed by a developed method with validations within acceptable limits. Ginsenoside Rg5 showed content of about 1% in FBPG. The results indicated that FBPG might have many different ginsenosides with diverse chemical structures, and the less polar ginsenosides were also important to the quality control and standardization of FBPG. View Full-Text
Keywords: 20(S)-methoxyl-ginsenoside Rg3; 20(R)-methoxyl-ginsenoside Rg3; isomer; quantification; flower buds of Panax ginseng 20(S)-methoxyl-ginsenoside Rg3; 20(R)-methoxyl-ginsenoside Rg3; isomer; quantification; flower buds of Panax ginseng
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Li, S.-S.; Li, K.-K.; Xu, F.; Tao, L.; Yang, L.; Chen, S.-X.; Gong, X.-J. A Strategy for Simultaneous Isolation of Less Polar Ginsenosides, Including a Pair of New 20-Methoxyl Isomers, from Flower Buds of Panax ginseng. Molecules 2017, 22, 442.

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